Publications by authors named "Tianshuo Chen"
Article Synopsis
- The FarmGTEx project aims to create a public database of genetic variants in livestock to connect genetic differences with physical traits, benefiting both animal breeding and human health research.
- The pilot phase, PigGTEx, involved analyzing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples from pigs, leading to the development of a genotype imputation panel and associations between millions of genetic variants and transcriptomic traits across 34 different tissues.
- The study highlights the tissue-specific regulatory effects of these variants, revealing molecular mechanisms affecting 207 complex pig traits while also demonstrating the relevance of pigs as models for understanding human gene expression and genetic regulation.
