Publications by authors named "Tianshou Sun"
Article Synopsis
- Tislelizumab combined with chemotherapy improves overall survival for patients with extensive-stage small-cell lung cancer (ES-SCLC) compared to chemotherapy alone, but its cost-effectiveness varies between the US and China.
- This study used a Markov state-transition model to assess the economic impact of this combination treatment from both US and Chinese healthcare perspectives, analyzing quality-adjusted life years (QALYs) and costs.
- The results showed that while tislelizumab plus chemotherapy might provide some benefit, it exceeds the willingness-to-pay thresholds in both countries, with probabilities of cost-effectiveness at 17.18% for China and 40.41% for the US.
[Inhibition of M2 macrophage polarization and reduction of airway inflammation in asthmatic mice with lncRNA MRAK088388 knockout].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2023
Objective To investigate the long non-coding RNA(lncRNA) MRAK08838 regulates macrophage function to influence the development of asthmatic airway inflammation. Methods MRAK088388 gene knockout (MRAK088388) mouse model was prepared and allergic asthma was induced by dust mite protein Dermatophagoides farinae 1 (Der f1). The mice were sacrificed after 28 days of modeling, and serum was collected to measure IgE and IgG.
View Article and Find Full Text PDFBackground: Airway remodeling in patients with asthma was correlated with induced epithelialmesenchymal transition (EMT) of bronchial epithelial cells.
Objective: This study examined the mechanism of Linc00511 on induced EMT of bronchial epithelial cells after transforming growth factor-β1 (TGF-β1) induction.
Methods: The human bronchial epithelial cell 16HBE was treated with 10 ng/mL TGF-β1 for 12 h, 24 h, or 48 h to induce EMT.