Publications by authors named "Tianshe He"
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people.
Immun Ageing
May 2024
Background: An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects.
View Article and Find Full Text PDFThe neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people.
Res Sq
March 2024
Background: An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated whether baseline gene expression could predict how well patients with eosinophilic esophagitis (EoE) would respond to topical corticosteroid treatment.
- Although a group of 22 genes showed a strong correlation with treatment non-response in the initial analysis, this finding did not hold up in an independent validation cohort.
- The researchers concluded that while their approach identified potential gene markers, further methods to predict treatment response are needed since the initial results were not confirmed in a larger group.