Publications by authors named "Tianqi Zhu"
Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans using a genetic risk score, there remains a notable gap in knowledge regarding Chinese populations. We conducted whole exome sequencing in a HSCR case cohort in Chinese.
View Article and Find Full Text PDFHydrogen sulfide (HS) functions as a signaling molecule affecting plant growth, development, and stress adaptation. Tall fescue (Festuca arundinacea Schreb.), a bioenergy crop, encounters significant challenges in agricultural production owing to low light by shading.
View Article and Find Full Text PDFBackground: Lobectomy resection is the standard treatment for patients with congenital pulmonary airway malformation (CPAM). However, accurate localization of CPAM lesions and avoiding excessive resection of normal lung tissue are one of the critical issues that can impact postoperative pulmonary function. Indocyanine green (ICG) can be adopted in lung preservation surgery, to minimize damage to normal lung tissue during thoracoscopic pneumonectomy.
View Article and Find Full Text PDFBackground: Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration.
Methods: A multicenter 1:1 matched case-control study was adopted, to compare the safety and efficacy of the ICG group (preoperative atomization inhalation of 0.5 mg/kg ICG solution) with traditional group (no preoperative atomization inhalation of ICG solution).
To acquire matrine derivatives with enhanced anticancer activity, we designed and synthesized twenty-one 15-site matrine based isatohydrazone derivatives were designed and synthesized. The anti-proliferative activity of all the compounds against human cervical cancer cells (HeLa), human colon cancer cells (HCT116), and non-small cell lung cancer cells (A549) was examined by the MTT method. The majority of the compounds exhibited superior anticancer activity compared to matrine.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the impact of cadmium (Cd) stress on agricultural soil and explores the potential of tall fescue, a grass species, in remediating heavy metals.
- By analyzing the microbial community structure in Cd-resistant (cv. 'Arid3') and Cd-sensitive (cv. 'Barrington') tall fescue, researchers used sequencing techniques to uncover differences in their responses to Cd stress.
- The findings suggest that specific bacteria and fungi from the 'Arid3' rhizosheath can enhance antioxidant systems and promote plant growth, indicating that the combination of tall fescue and its associated microbes could be effective in cleaning up contaminated soils.
Regulatory mechanism of strigolactone in tall fescue to low-light stress.
Plant Physiol Biochem
October 2024
Article Synopsis
- The study investigates the effects of strigolactone (SL), a plant hormone, on tall fescue (Festuca arundinacea) under low-light conditions, focusing on its growth and physiological traits.* -
- Results indicate that the SL analog GR24 improves plant height, leaf width, and biomass, while reducing tiller numbers and enhancing photosynthesis efficiency and antioxidant levels.* -
- The findings suggest SL helps tall fescue tolerate low light conditions by increasing hormone concentration and gene expression related to shade tolerance, with some validation done using Arabidopsis.*
Article Synopsis
- The study investigates the use of Ga-labelled fibroblast activation protein inhibitor-04 (Ga-FAPI-04) PET/MR imaging to evaluate myocardial fibrosis in STEMI patients.
- It includes 33 patients, with findings showing that those who experienced worsening renal function (WRF) had higher Ga-FAPI-04 uptake, indicating a potential link between myocardial fibroblast activation and kidney health.
- Ga-FAPI-04 uptake at baseline is identified as a predictor for WRF, suggesting that this imaging technique could provide valuable insights into renal function post-STEMI.
Article Synopsis
- Porcine oocytes have low in vitro maturation efficiency, but melatonin, produced by mitochondria in these oocytes, may enhance their quality and maturation by reducing reactive oxygen species (ROS) and increasing ATP production.
- Knocking down melatonin production with siRNA leads to abnormal mitochondrial distribution and decreased ATP, hindering oocyte maturation, but these issues can be fixed with melatonin supplementation.
- The beneficial effects of melatonin are likely mediated by its membrane receptors, as indicated by the blocking effects of the antagonist Luzindole, highlighting the mitochondrial role in melatonin synthesis for improved oocyte maturation.
Article Synopsis
- The "Three Rural Issues" focus on agriculture, farmers, and rural areas, which are vital for China’s rural revitalization efforts, particularly through enhancing farmer entrepreneurship.* -
- The study uses 2020 data to explore how participation in rural e-commerce influences farmer entrepreneurial behavior, revealing that e-commerce significantly boosts such activities and acts as a mediator between various factors like social trust and human capital.* -
- Key findings indicate that better network infrastructure and human capital increase the likelihood of farmers choosing entrepreneurship, leading to policy recommendations aimed at improving infrastructure and education to support rural revitalization.*
Article Synopsis
- The study investigates how enteric neural crest cells (ENCCs) develop and migrate to colonize the gut, using advanced techniques like single-cell RNA sequencing.
- It identifies specific transcription factors and key signaling pathways (ephrin-Eph, Wnt-Frizzled, and Sema3a-Nrp1) that guide ENCC interactions with surrounding cells.
- The findings also connect disruptions in these pathways to conditions like Hirschsprung's disease, highlighting their importance in gut development and potential disorders.
Article Synopsis
- * A new computational method called SRY was developed, improving chromosome assembly, especially in challenging regions, and works well with existing hybrid assembly software.
- * This advancement allows for complete genome assemblies, paving the way for better research opportunities related to sex-limited chromosomes.
Article Synopsis
- Optically active spin defects, like nitrogen-vacancy centers, are useful for studying nuclear spin clusters due to their high sensitivity and ability to provide atomic-scale insights.
- The research introduces advanced Fourier spectroscopy techniques to enhance the mapping and localization of carbon-13 nuclear spins around these defects at room temperature.
- The study showcases two applications of multidimensional NMR: improved localization of nuclear spins by separating hyperfine components and editing spectral data of nuclear-spin pairs to measure internuclear coupling constants, thus offering new methods for analyzing molecular structures.
Article Synopsis
- The study investigates the use of Mesenchymal stem cells (MSCs) as a therapy for Hirschsprung disease-associated enterocolitis (HAEC), a serious complication of Hirschsprung disease.
- It involved experiments on HSCR and HAEC patients, along with a mouse model, to assess how effective and safe MSCs are in reducing inflammation and improving intestinal condition.
- Results showed that MSCs reduced harmful M1 macrophages and pro-inflammatory cytokines while increasing anti-inflammatory cytokines, suggesting a COX-2 dependent mechanism that could lead to new treatments for HAEC.
Article Synopsis
- - The regulation of mRNA after transcription is vital for gene expression, and disruptions can lead to developmental issues and diseases, hence researching post-transcriptional regulators is important for understanding these processes.
- - The study identifies FAM46C, a non-canonical RNA poly(A) polymerase, as essential for red blood cell development, with its expression peaking during late erythroid stages and regulated by a specific enhancer.
- - FAM46C helps stabilize mRNA and directs erythroid differentiation, specifically targeting components related to lysosomes and mitochondria, which is crucial for the maturation of red blood cells and maintaining cellular balance.
Article Synopsis
- A study analyzed stingless bee honeys (SBHs) from Australian and Malaysian species for harmful pyrrolizidine alkaloids (PAs) using advanced mass spectrometry techniques.
- Low levels of PAs were detected against certified standards, but untargeted analysis identified additional alkaloid isomers linked to a nearby PA weed species.
- The research emphasizes the importance of recognizing local PA sources for honey producers, as not all PAs may be captured in standard tests, with some identified compounds potentially being less toxic.
Article Synopsis
- Obstructive sleep apnea (OSA) is linked to increased risk of ST-segment elevation myocardial infarction (STEMI) during the night, with this study examining the timing and frequency of STEMI occurrences in OSA patients compared to non-OSA patients.
- In a study of 397 patients, 33% of those with OSA experienced STEMI onset between midnight and 5:59 am, significantly higher than the 15% in non-OSA patients, indicating a nearly threefold increased risk of STEMI during these hours for OSA patients.
- Over a follow-up period of nearly three years, STEMI onset times in OSA patients were associated with a heightened risk of adverse cardiovascular and cerebrovascular events
Article Synopsis
- * Researchers enhance the SNR by coupling individual NVs to specially designed diamond nanopillars, which improve the efficiency of fluorescence collection.
- * The study confirms that taller nanopillars with tapered sides significantly boost SNR, making the devices easier to use with simpler optical equipment, ultimately enhancing measurement precision for scanning applications.
Article Synopsis
- The study investigated left ventricular remodeling (LVR) in patients with acute STEMI who were treated with primary percutaneous coronary intervention (PCI), focusing on the connection between early left ventricular dilation and later LVR outcomes.
- Out of 301 patients, 18.9% experienced LVR, with significant differences in left ventricular end-diastolic volume (LVEDV) changes between those with LVR and those without during follow-up.
- Early measurement of changes in LVEDV after discharge and at 1 month was effective in predicting late LVR at the 6-month mark, suggesting that consistent monitoring may improve patient outcomes.
Article Synopsis
- Cholangitis is a common complication in patients who have undergone Kasai portoenterostomy (KPE) for biliary atresia, and timely treatment with antibiotics is critical due to uncertain bacterial infection.
- This study included a multicenter, randomized trial where patients with different severities of cholangitis were treated with various combinations of antibiotics, focusing primarily on the effectiveness of cefoperazone sodium tazobactam sodium (CSTS) and meropenem (MEPM).
- Results showed no significant differences in outcomes like fever duration or liver function recovery between CSTS and MEPM in mild cases, but severe cases benefitted from MEPM combined with immunoglobulin (IVIG), reducing fever duration and improving
Article Synopsis
- Cross-species introgression can skew estimates of when species diverged if not taken into account during phylogenomic analysis.
- Using simulations, the study demonstrated that incorporating introgression into the multispecies coalescent (MSC) framework leads to more accurate divergence time estimates.
- The results were further validated with real data from baobabs and Jaltomata species, showing that the new multispecies-coalescent-with-introgression (MSci) model can reliably handle cases of introgression while estimating divergence times.
Article Synopsis
- * Out of 847 patients, those who achieved optimal LDL-C levels (below 1.4 mmol/L and a reduction of at least 50% from baseline) showed a significantly lower rate of NTL plaque progression compared to those in the non-optimal group.
- * Both univariate and multivariate logistic regression analyses identified achieving the recommended LDL-C levels as an independent protective factor against NTL plaque progression, suggesting that managing LDL-C effectively may reduce future cardiac events.