Publications by authors named "Tianqi Xu"

Gut microbiota plays a crucial role in resisting the invasion of pathogens, particularly multidrug-resistant (MDR) bacteria, which pose a significant threat to public health. While exercise offers numerous health benefits, its impact on host colonization resistance remains largely unclear. In this study, we demonstrate that moderate exercise significantly reduces gut colonization by methicillin-resistant Staphylococcus aureus (MRSA), a clinically important MDR pathogen.

View Article and Find Full Text PDF

Current researches on sodium penetration in electrolytic aluminum cathode carbon blocks primarily measure cathode expansion curves, showing mostly macroscopic characteristics. However, the microscopic structure is often underexplored. As a porous medium, the diffusion performance of cathode carbon blocks is closely tied to their internal pore structure.

View Article and Find Full Text PDF

Patients with spinal cord injury (SCI) may develop depression, which can affect their rehabilitation. However, the underlying mechanism of depression in SCI patients remains unclear. Previous studies have revealed increased p38 MAPK phosphorylation in the rat hippocampus after SCI, accompanied by depression-like behaviors.

View Article and Find Full Text PDF

Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progressively deciphering its molecular underpinnings; the future of psoriasis diagnostics may involve genetic and immunological profiling to pinpoint biomarkers, enabling more accurate and timely interventions.

View Article and Find Full Text PDF

Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a high prevalence. Recent data suggest that NAFLD may be an independent risk factor for cardiovascular disease (CVD). This study aimed to investigate the association between NAFLD and carotid high-risk plaque (HRP) as assessed by high-resolution magnetic resonance imaging (MRI), and to examine the diagnostic value of NAFLD.

View Article and Find Full Text PDF

Introduction: Our collaborative team has previously developed a prognostic model for acute ischemic stroke (AIS). This model, known as the clinical decision support system (CDSS), aims to provide personalized assistance to clinicians in making treatment decisions and improving patient prognosis. The objective of this study was to externally validate the model using Chinese AIS patients.

View Article and Find Full Text PDF

Introduction: Salmonella, a foodborne zoonotic pathogen, is a significant cause of morbidity and mortality in animals and humans globally. With the prevalence of multidrug-resistant strains, Salmonellosis has become a formidable challenge. Host-directed therapy (HDT) has recently emerged as a promising anti-infective approach for treating intracellular bacterial infections.

View Article and Find Full Text PDF

Tigecycline is a last-resort antibiotic to treat complicated infections caused by multidrug-resistant pathogens, while the emergence of plasmid-mediated tet(X) family severely compromises its clinical efficacy. Novel antimicrobial strategies not limited to new antibiotics in pharmaceutical pipeline are urgently needed. Herein, we reveal the metabolic disparities between tet(X)-negative and -positive E.

View Article and Find Full Text PDF

Aim: This study assessed the predictive value of pericarotid fat density (PFD) on carotid computed tomography angiography (CTA) for recurrent ischemic stroke or transient ischemic attack (TIA).

Methods: In total, 739 patients who underwent CTA between January 2014 and December 2021 were retrospectively included in this study. The PFD was evaluated using carotid CTA.

View Article and Find Full Text PDF

Introduction: It was reported that most arachnoid cyst (AC)-associated chronic subdural hematoma (CSDH) was spontaneous. However, AC with CSDH caused by trauma was extremely scarcely reported. In this paper, the authors reported a successful surgical treatment of a case of AC associated with CSDH after trauma.

View Article and Find Full Text PDF

Background: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor that poses a significant threat to human health. Patients are often diagnosed at advanced stages of the disease, resulting in poor clinical outcomes and a short survival period. Recent advances have revealed that ESCC tumors exhibit distinct molecular biological characteristics.

View Article and Find Full Text PDF

Purpose: Based on coronary computed tomography angiography (CCTA), this study aimed to evaluate the predictive value of pericoronary fat attenuation index (FAI) for graft occlusion in patients following coronary artery bypass grafting (CABG).

Materials And Methods: The clinical and imaging data of 100 patients with coronary artery disease (CAD) who underwent CCTA and subsequently received successful CABG between December 2012 and March 2024 were retrospectively collected. According to the subsequent CCTA evaluation of grafts, they were categorized into occlusion group (n = 27) and patency group (n = 73).

View Article and Find Full Text PDF
Article Synopsis
  • Glioblastoma (GBM) is a highly aggressive brain cancer with poor survival rates, underscoring the urgent need for new treatments targeting its underlying biology.
  • Research focused on glioblastoma stem cells (GSCs) revealed that the protein PDCD6 is expressed at higher levels in GBM tissues and is associated with decreased patient survival.
  • The study indicates that targeting PDCD6 may improve treatment outcomes by reducing the aggressive stem-like properties of GBM cells.
View Article and Find Full Text PDF

Archaea play a significant role in natural ecosystems and the human body. Archaeal viruses exert a considerable influence on the structure and composition of archaeal communities and their associated ecological environments. The present study revealed the complete genomes of 38 archaeal head-tailed proviruses through comprehensive data mining.

View Article and Find Full Text PDF

Animal behavior is organized into nested temporal patterns that span multiple timescales. This behavior hierarchy is believed to arise from a hierarchical neural architecture: Neurons near the top of the hierarchy are involved in planning, selecting, initiating, and maintaining motor programs, whereas those near the bottom of the hierarchy act in concert to produce fine spatiotemporal motor activity. In , behavior on a long timescale emerges from ordered and flexible transitions between different behavioral states, such as forward, reversal, and turn.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explores how gut microbiota affects polyamine metabolism, revealing that germ-free mice have higher polyamine levels in their colon compared to those with gut bacteria.
  • - It highlights that small RNA molecules from the gut can lower polyamine levels by inhibiting enzymes involved in their metabolism, which impacts recovery from conditions like colitis.
  • - Furthermore, a decrease in these small RNAs in colorectal cancer patients correlates with increased polyamine levels, suggesting that gut bacteria's role in regulating polyamine metabolism might be a target for treating related diseases.
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the link between non-alcoholic fatty liver disease (NAFLD) and the risk of recurrent strokes or transient ischemic attacks (TIA) in 742 participants with carotid atherosclerosis, using data from carotid CT angiography.
  • - Findings show a significant association between NAFLD and increased rates of recurrent stroke/TIA, with patients suffering from NAFLD having a lower event-free survival rate than those without the condition.
  • - The results highlight NAFLD’s potential as a valuable imaging marker in predicting and preventing cardiovascular diseases, supported by a predictive model that combines NAFLD with clinical and plaque features, achieving an Area Under the Curve (AUC) of 0.79
View Article and Find Full Text PDF
Article Synopsis
  • * A newly identified resistance pump gene is reducing the effectiveness of tigecycline, but research shows that adding inosine can counteract this resistance by improving drug uptake and altering bacterial metabolism.
  • * This study highlights the potential of inosine as a co-treatment strategy to enhance the effectiveness of tigecycline against resistant bacterial infections.
View Article and Find Full Text PDF
Article Synopsis
  • AHPND is a severe shrimp disease caused by a specific strain of Vibrio that contains the virulence plasmid pAHPND with key genes (pirAB) responsible for its lethality.
  • Researchers identified a genetic element related to another bacterium and discovered two related plasmids (pAHPND-r1 and pAHPND-r2) that might have contributed to the creation of pAHPND.
  • The study suggests that the emergence of pAHPND involved genetic recombination processes, leading to the effective horizontal transfer of this plasmid, which is crucial for understanding how the disease spreads among shrimp populations.
View Article and Find Full Text PDF

Assembling graphene sheets into macroscopic fibers with graphitic layers uniaxially aligned along the fiber axis is of both fundamental and technological importance. However, the optimal performance of graphene-based fibers has been far lower than what is expected based on the properties of individual graphene. Here we show that both mechanical properties and electrical conductivity of graphene-based fibers can be significantly improved if bridges are created between graphene edges through covalent conjugating aromatic amide bonds.

View Article and Find Full Text PDF

Previous studies on the early interference of gut microbiota by () in weaned piglets are rarely reported, and the present trial is a preliminary study. This experiment was conducted to investigate the effects of supplementation on the growth performance, serum biochemistry, immune response, fecal short-chain fatty acids and microbiota of weaned piglets. Sixty weaned piglets were randomly divided into a control group (CON) and a group (BS), which were fed a basal diet and the basal diet supplemented with 5 × 10 CFU per kg, respectively.

View Article and Find Full Text PDF
Article Synopsis
  • - Activation of the renin-angiotensin system (RAS) leads to oxidative stress and inflammation in the hypothalamic paraventricular nucleus (PVN), causing sympathetic hyperactivity and contributing to hypertension.
  • - A study on 2-kidney one-clip (2K1C) rats found that pyridostigmine improved cardiovascular function and lowered blood pressure by restoring autonomic balance and reducing levels of inflammatory cytokines and oxidative stress markers in the PVN.
  • - Pyridostigmine also inhibited the RAS in the PVN by decreasing levels of angiotensin-converting enzyme (ACE) and angiotensin II, while increasing expression of the angiotensin II type 2 receptor
View Article and Find Full Text PDF
Article Synopsis
  • Transcranial focused ultrasound (tFUS) is a noninvasive method that effectively stimulates brain regions, and this study focused on its role in activating Piezo1 and Piezo2 ion channels in the mouse motor cortex to influence motor responses.
  • Researchers knocked down Piezo1 and Piezo2 in mice and found that these knockdowns resulted in lower success rates and longer response times for motor tasks when stimulated with tFUS, compared to control mice.
  • The study concluded that Piezo channels are critical for the effectiveness and timing of responses to tFUS stimulation, highlighting the potential for this research to inform new treatments for neurological disorders.
View Article and Find Full Text PDF
Article Synopsis
  • Cell transplantation shows promise for treating spinal cord injuries, but there's no agreement on the best carrier scaffolds to use for hosting the cells.
  • This study investigated the effectiveness of different material scaffolds in rats, involving 25 studies that compared outcomes in those receiving natural or synthetic scaffolds.
  • Results indicated that while natural and synthetic scaffolds performed similarly in restoring motor function, factors like the type and number of cells used could influence treatment success, warranting further research with larger clinical trials.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiongeb8denv9ji47eihemk0o1pcv5qbak6s): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once