Large-scale sensitivity adjustment for Gd-HMME room temperature phosphorescence oxygen sensing.

The oxygen sensing enhancement based on room temperature phosphorescence (RTP) of Gd-HMME adjusted by imidazole was studied. The phosphorescence intensity I and the Stern-Volmer equations under different imidazole concentration were obtained, and the physical mechanism of imidazole regulating the oxygen quenching constant K was analyzed. It was found that the K value increased by ∼46 folds in the range of 12.

Involvement of hydrogen peroxide in sonodynamical effect with sinoporphyrin sodium in hypoxic situation.

Sonodynamic therapy (SDT) represents a noninvasive therapeutic method the activation of certain chemical sensitizers using low-intensity ultrasound to generate various reactive oxygen species (ROS). In this work, we conducted systematic experiments to evaluate the production of hydrogen peroxide (HO) in sinoporphyrin sodium (DVDMS) mediated SDT (DVDMS-SDT). We found that the fluorescence intensities of HO-specific probe BES-HO and Amplex Red increased significantly exposure to DVDMS-SDT while decreased with the introduction of catalase (HO scavenger), indicating the production of HO.

Investigation of high-concentration doping performance based on Er-ion-doped BaGdTiO.

Recently, various strategies have been explored during research into the use of lanthanide-doped luminescent materials to mitigate energy loss at elevated dopant concentrations. Herein we report Yb3+/Er3+ co-doped Ba6Gd2Ti4O17 (BGTO) phosphors with a laminated lattice structure, which can allow the high-concentration doping of Er3+ ions into the oxide. Detailed investigations into the luminescence properties and crystal structures of Yb3+/Er3+ co-doped BGTO reveal that an increase in the dopant concentration is associated with the dimensional limitation of energy transfer in the crystal lattice.

An effective oxygen content detection in phosphorescence of PtOEP-C6/Poly (St-co-TFEMA).

The phosphorescence of PtOEP-C6/Poly (St-co-TFEMA) has been investigated to achieve an accurate oxygen content, which is always puzzled as its extreme temperature sensitivity. The relations of oxygen content and phosphorescence intensity ratio can be perfectly fitted by the Stern-Volmer equation at different temperatures, meanwhile the monotonic quenching constant K is obtained, which enables us to develop a method of temperature correction to realize the intrinsic oxygen content. Then a clear fundamental picture of the temperature quenching mechanism of PtOEP is drawn by the time-resolved spectroscopy, the temperature sensitivity of phosphorescence arises from the enhanced quenching effect of oxygen by temperature.

Reactive oxygen species explicit dosimetry to predict local tumor growth for Photofrin-mediated photodynamic therapy.

Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates (). A macroscopic model was adopted to calculate reactive oxygen species concentration ([]) to predict Photofrin-PDT outcome in mice bearing radiation-induced fibrosarcoma (RIF) tumors. Singlet oxygen is the primary cytotoxic species for ROS, which is responsible for cell death in type II PDT, although other type I ROS is included in the parameters used in our model.

Reactive oxygen species explicit dosimetry to predict tumor growth for benzoporphyrin derivative-mediated vascular photodynamic therapy.

Photodynamic therapy (PDT) is a well-established treatment modality for cancer and other malignant diseases; however, quantities such as light fluence and PDT dose do not fully account for all of the dynamic interactions between the key components involved. In particular, fluence rate (ϕ) effects, which impact the photochemical oxygen consumption rate, are not accounted for. In this preclinical study, reacted reactive oxygen species ([ROS]) was investigated as a dosimetric quantity for PDT outcome.

Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy.

Explicit dosimetry of treatment light fluence and implicit dosimetry of photosensitizer photobleaching are commonly used methods to guide dose delivery during clinical PDT. Tissue oxygen, however, is not routinely monitored intraoperatively even though it is one of the three major components of treatment. Quantitative information about in vivo tissue oxygenation during PDT is desirable, because it enables reactive oxygen species explicit dosimetry (ROSED) for prediction of treatment outcome based on PDT-induced changes in tumor oxygen level.

Reactive oxygen species explicit dosimetry to predict local tumor control for Photofrin-mediated photodynamic therapy.

Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates (). A macroscopic model was adopted to calculate reactive oxygen species concentration ([ROS]) to predict Photofrin-PDT outcome in mice bearing radiation-induced fibrosarcoma (RIF) tumors. Singlet oxygen is the primary cytotoxic species for ROS, which is responsible for cell death in type II PDT, although other type I ROS is included in the parameters used in our model.

Reactive oxygen species explicit dosimetry to predict tumor growth for BPD-mediated vascular photodynamic therapy.

Photodynamic therapy (PDT) is a well-established treatment modality for cancer and other malignant diseases; however, quantities such as light fluence, and PDT dose do not fully account for all of the dynamic interactions between the key components involved. In particular, fluence rate () effects are not accounted for, which has a large effect on the oxygen consumption rate. In this preclinical study, reacted reactive oxygen species ([ROS]) was investigated as a dosimetric quantity for PDT outcome.

Photoluminescence properties and spectral structure analysis of NaLn(MoO4)2:Eu3+ (Ln = Gd, Y) phosphors.

In this paper, a facile synthetic route for the preparation of NaLn(MoO4)2:Eu3+ (Ln = Gd, Y) nanocrystals by a hydrothermal method is reported. The NaLn(MoO4)2:Eu3+ (Ln = Gd, Y) micro-powders were synthesized by a high temperature solid-state reaction. The optical properties of Eu3+ as a local structural probe are analyzed when being incorporated into NaLn(MoO4)2 (Ln = Gd, Y) micro-powders and nanocrystals.