Yb/Er/Ho-engineered rare earth fluoride nanoparticles to unlock multimodal medical imaging.

Fluorescence imaging with advanced multi-channel observation, high sensitivity, and high spatio-temporal resolution holds great promise for biomedical applications. However, the different absorption and scattering spectra of complex tissue structures present significant challenges for real-time investigations of live biological and physiological processes. Herein, we present Yb/Er/Ho-engineered rare earth fluoride nanoparticles with integrated multimodal imaging functions that can provide synergistic effects over any modality alone.

Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway.

Objective: NLRP3 inflammasome may play a key role in OA pathogenesis. Stromal cell-derived factor-1 (SDF-1) is a homeostatic CXC chemokine. Since the role of SDF-1 in OA has not been explored, this study aimed to examine the effect of SDF-1 on NLRP3 inflammasome and pyroptosis in synoviocytes from OA joints.

Analysis of the clinical significance of DCLK1 colorectal cancer using novel monoclonal antibodies against DCLK1.

Introduction: Doublecortin-like kinase 1 (DCLK1) is considered a putative tumor stem cell (TSC) marker and a promising therapeutic target, as DCLK1 progeny cells exhibit high expression in tumors. However, the biological function of DCLK1 cells in tumorigenesis and tumor progression remains unclear.

Materials And Methods: We generated rabbit monoclonal antibodies (mAbs) against DCLK1, DCLK1-42, and DCLK1-87 mAbs, using a novel chip-based immunospot array assay on a chip system.