Comprehensive analysis of circRNA expression profiles in postmenopausal women differing in bone mineral density.

Postmenopausal osteoporosis (PMOP) seriously endangers the bone health of older women. Although there are currently indicators to diagnose PMOP, early diagnostic biomarkers are lacking. Circular ribonucleic acid (circRNA) has a stable structure, regulates gene expression, participates in the pathological process of disease, and has the potential to become a biomarker.

Sea-urchin-like covalent organic framework as solid-phase microextraction fiber coating for sensitive detection of trace pyrethroid insecticides in water.

Pyrethroid insecticides residues in water pose a critical threat to the environment from widespread production and overuse. Therefore, it is of major relevance to develop a sensitive and efficient method to detect pyrethroid insecticides in water. In this paper, a covalent organic framework (COF) with NHCO as the structural unit was synthesized using a simple condensation reaction of TTL (NH) and TDBA (COOH).

Comprehensive analysis of lncRNA expression profiles in postmenopausal osteoporosis.

To explore the key lncRNAs affecting postmenopausal osteoporosis (PMOP) progression, the transcriptome sequencing of peripheral blood mononuclear cells from fifteen early postmenopausal women, according to bone mineral density, were divided into groups of osteoporosis, osteopenia and normality, in each of which the expression profiles of lncRNAs was investigated. From the results we observed nine candidates of lncRNAs, which were to be compared with miRBase, and found that MIR22HG as one candidate of lncRNA was most likely to be directly used as miRNA precursor. Based on the KEGG annotation and lncRNA-miRNA-mRNA-KEGG network, we analyzed the potential role of candidate lncRNAs.

The therapeutic potential of mesenchymal stem cells in treating osteoporosis.

Osteoporosis (OP), a common systemic metabolic bone disease, is characterized by low bone mass, increasing bone fragility and a high risk of fracture. At present, the clinical treatment of OP mainly involves anti-bone resorption drugs and anabolic agents for bone, but their long-term use can cause serious side effects. The development of stem cell therapy and regenerative medicine has provided a new approach to the clinical treatment of various diseases, even with a hope for cure.

Valley Vortex Assisted and Topological Protected Microparticles Manipulation with Complicated 2D Patterns in a Star-like Sonic Crystal.

Arranging microparticles into desired patterns, especially in a complicated pattern with a reliable and tunable manner, is challenging but highly desirable in the fields such as biomedicine and tissue engineering. To overcome these limitations, here, by using the concept of topology in acoustics, the valley vortex is utilized to manipulate particles on a large scale with complicated 2D patterns in the star-like sonic crystals at different frequencies. A topologically protected edge state is obtained at the interface of the crystals with different valley Hall phases, which shows the ability of reliable microparticles control along the sharp corner and the capability of robust particles cluster aggregation in a defective system.

Comparative profile of exosomal microRNAs in postmenopausal women with various bone mineral densities by small RNA sequencing.

To explore the role of plasma miRNAs in exosomes in early postmenopausal women. Small RNA sequencing was implemented to clarify the expression of miRNA in plasma exosomes obtained from 15 postmenopausal women, divided into groups of osteoporosis, osteopenia, and normal bone mass based on bone mineral density. Differentially expressed miRNAs (DEMs) were identified by comparing miRNA expression profiles.

Postoperative complications of concomitant fat embolism syndrome, pulmonary embolism and tympanic membrane perforation after tibiofibular fracture: A case report.

Background: Fat embolism syndrome (FES) is a rare disease characterized by pulmonary distress, neurologic symptoms, and petechial rash and seriously threatens human life and health. It is still neglected clinically because of the lack of verifiable diagnostic criteria and atypical clinical symptoms. No studies on FES with pulmonary embolism (PE) and tympanic membrane perforation have been reported to date.

Elastic Waves in Curved Space: Mimicking a Wormhole.

Transformation optics (TO) can be used to investigate nontrivial spacetime structures with inhomogeneous materials. However, the extreme curvature and large refractive indices make the implementation of a wormhole challenging. By considering flexural waves on a curved plate with geometric curvature, the stringent material requirement can be relaxed, and we demonstrate a two-dimensional analog of a wormhole using homogeneous materials within a curved laboratory frame.

Parametric Excitation of Optomechanical Resonators by Periodical Modulation.

Optical excitation of mechanical resonators has long been a research interest, since it has great applications in the physical and engineering field. Previous optomechanical methods rely on the wavelength-dependent, optical anti-damping effects, with the working range limited to the blue-detuning range. In this study, we experimentally demonstrated the excitation of optomechanical resonators by periodical modulation.

Ultra-Broadband Acoustic Diode in Open Bend Tunnel by Negative Reflective Metasurface.

We theoretically and numerically propose an open bend tunnel with the capability of realizing ultra-broadband unidirectional transmission. The designed tunnel can isolate acoustic wave incidence from opposite directions and substance like the fluids or objects can exchange freely by employing acoustic gradient metasurface. The underlying mechanism is due to apparent negative reflection in ultra-broadband frequency range when the incoming angle impinging on the metasurface is over the critical incidence.

Nanometer-precision linear sorting with synchronized optofluidic dual barriers.

The past two decades have witnessed the revolutionary development of optical trapping of nanoparticles, most of which deal with trapping stiffness larger than 10 N/m. In this conventional regime, however, it remains a formidable challenge to sort out sub-50-nm nanoparticles with single-nanometer precision, isolating us from a rich flatland with advanced applications of micromanipulation. With an insightfully established roadmap of damping, the synchronization between optical force and flow drag force can be coordinated to attempt the loosely overdamped realm (stiffness, 10 to 10 N/m), which has been challenging.

Hybrid acoustic metamaterial as super absorber for broadband low-frequency sound.

A hybrid acoustic metamaterial is proposed as a new class of sound absorber, which exhibits superior broadband low-frequency sound absorption as well as excellent mechanical stiffness/strength. Based on the honeycomb-corrugation hybrid core (H-C hybrid core), we introduce perforations on both top facesheet and corrugation, forming perforated honeycomb-corrugation hybrid (PHCH) to gain super broadband low-frequency sound absorption. Applying the theory of micro-perforated panel (MPP), we establish a theoretical method to calculate the sound absorption coefficient of this new kind of metamaterial.

Plate-type elastic metamaterials for low-frequency broadband elastic wave attenuation.

In this paper, we numerically and experimentally demonstrate the low-frequency broadband elastic wave attenuation and vibration suppression by using plate-type elastic metamaterial, which is constituted of periodic double-sides stepped resonators deposited on a two-dimensional phononic plate with steel matrix. The dispersion relations, the power transmission spectra, and the displacement fields of the eigenmodes are calculated by using the finite element method. In contrast to the typical phononic plates consisting of periodic stepped resonators deposited on a homogeneous steel plate, the proposed elastic metamaterial can yield large band gap in the low-frequency range, resulting in the low-frequency broadband elastic wave attenuation.

Numerical and analytical solutions for sound propagation and absorption in porous media at high sound pressure levels.

On the basis of the work of Wilson et al. [J. Acoust.

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice.

A novel three-dimension micro-device was formulated to control delivery of 5-fluorouracil (5-FU) for the treatment of solid tumors. The poly-(lactic-co-glycolic) acid (PLGA), which is both biocompatible and biodegradable, was used as carrier material. The characteristics of drug release in vitro and in vivo and the performance of the micro-device after implantation in tumor bearing mice were evaluated.

[High-performance liquid chromatography-based determination of plasma and renal tissue cisplatin levels after subcutaneous cisplatin implantation in mice].

Objective: To develop a method for determining plasma and renal tissue concentrations of cisplatin (DDP) after subcutaneous DDP implantation in mice.

Methods: DDP was extracted from the plasma and tissue of mice receiving subcutaneous DDP implantation and reacted with sodium diethyldithiocarbamate (DDTC). The product Pt (DDTC)(2) extracted by diethyl ether was determined using high-performance liquid chromatography (HPLC) with the mobile phase of water and methanol at the ratio of 25:75 and the flow rate of 1.