Publications by authors named "Tianlin Zhou"

Background: The brain in resting state has complex dynamic properties and shows frequency dependent characteristics. The frequency-dependent whole-brain dynamic changes of resting state across the scans have been ignored in Alzheimer's disease (AD).

Objective: Coactivation pattern (CAP) analysis can identify different brain states.

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Article Synopsis
  • Research identifies three key brain networks that are affected during resting states in Alzheimer's patients: the default mode network (DMN), salient network (SN), and central executive network (CEN).
  • Using an innovative method called energy landscape, the study examines how these networks function differently in Alzheimer's patients compared to healthy individuals.
  • Findings reveal that Alzheimer's patients exhibit unstable brain dynamics with heightened flexibility in state transitions, which correlates with clinical symptoms, thus shedding light on the underlying mechanisms of brain activity in the condition.
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Background: Factor (F)XI contributes to thrombosis development while it plays a limited role in normal hemostasis. FXI targeting has the potential for preventing and treating thrombosis with little bleeding risk.

Objectives: The aim of this study was to develop novel antibody therapeutics against FXI for the treatment of thrombosis-related diseases.

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Necroptosis, which is recently recognized as a form of programmed cell death, plays a critical role in cancer biology, including tumorigenesis and cancer immunology. It was recognized not only to defend against tumor progression by suppressing adaptive immune responses but also to promote tumorigenesis and cancer metastasis after recruiting inflammatory responses. Thus the crucial role of necrosis in tumorigenesis has attracted increasing attention.

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In recent years, Non-Hodgkin lymphoma (NHL) has been one of the most fast-growing malignant tumor diseases. NHL poses severe damages to physical health and a heavy burden to patients. Traditional therapies (chemotherapy or radiotherapy) bring some benefit to patients, but have severe adverse effects and do not prevent relapse.

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Oral squamous cell carcinoma (OSCC) is one of the most common cancers in developing countries particularly in those aged over 50. Traditional treatment is with surgery, radiotherapy, chemotherapy, or a combination of these which often results in considerable discomfort to the patient. Here we describe a potential alternative which employs a near-infrared (NIR) responsive dissolvable microneedle system (HMPBs&DOX@HA MNs) made of hyaluronic acid (HA) with hollow mesoporous Prussian blue nanoparticles (HMPBs) loaded with doxorubicin (DOX).

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Objective: To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs).

Methods: We employed a with-in group repeated measures design with an anode HD-tDCS protocol (2 mA, 20 min, the precuneus) on 11 (2 vegetative state and nine minimally conscious state) patients with DOCs. MMN and Coma Recovery Scale-Revised (CRS-R) scores were measured at four time points: before the treatment of HD-tDCS (T0), after a single session of HD-tDCS (T1), after the treatment of 7 days (T2) and 14 days (T3).

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CSCs are able to survive routine anticancer procedures and peripheral-immune attack. Here we develop and detail a framework of CSC elimination governed by 3D-biologics. Pluripotent cells-engineered 3D-biologics (PMSB) and control non-3D-biologics were prepared from placenta-based somatic stem cells (PSCs) and inoculated respectively into senile hosts bearing progressive mammary, lung, colon carcinomas and melanoma.

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Objective: To optimize the technology of enzymolysis extraction of total anthraquinones.

Methods: Used the total anthraquinone concentration extracted from rhubarb (Rheum palmatum, L) via enzymolysis as experimental assess index, effect of enzyme dose, enzyme solution temperature, enzyme solution time and pH on total anthraquinone extraction were investigated respectively based on single factor variance analysis. Furthermore, its extraction process was optimized based on response surface methodology.

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Tb(III) complexes were prepared from Tb(NO(3))(3)·6H(2)O and four Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde with aroylhydrazines. X-ray crystal and other structural analyses indicate that Tb(III) and every ligand can form a binuclear Tb(III) complex with 1:1 metal-to-ligand stoichiometry and nine-coordination at the Tb(III) center. Viscosity titration experiments and fluorescent and ultraviolet-visible (UV-Vis) spectroscopy results indicate that all the Tb(III) complexes can bind to Calf thymus DNA through intercalation with the binding constants at the order of magnitude of 10(6)-10(7) M(-1), and they may be used as potential anticancer drugs, but complexes containing active phenolic hydroxy groups may have stronger antitumor activities.

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Taking the secondary natural Pinus tabulaeformis forest in hilly loess region as research object, the shape, size structure, distribution, gap-maker features, and renewal dynamics of gaps were investigated. The results showed that the areas of canopy gap (CG) and extended gap (EG) appeared to have a skewed and small gap- dominated distribution. The CGs had an average area of 31.

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Although it has long been presumed that peripheral populations tend to exhibit low genetic diversity because of isolation and genetic drift, results of empirical investigation remain ambiguous. Some chukar partridge (Alectoris chukar) populations have expanded their ranges, resulting in several peripheral populations, due to recent deforestation by human beings in the Longdong Loess Plateau of northwestern China. On the basis of mitochondrial DNA control-region data, we compare the genetic diversity of two peripheral populations, Honghui and Wangxia, and six central populations.

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