New pentacyclic triterpenoids isolated from and their hepatoprotective activities on -butyl hydroperoxide-induced oxidative injury.

Eight unknown pentacyclic triterpenoids (1-4 and 8-11), along with eight known analogues (5-7 and 12-16) have been first isolated from the dried whole plant of . The structures of the new compounds were determined by comprehensive spectroscopic methods, including 1D and 2D NMR, as well as HRESIMS measurements. Meanwhile, the hepatoprotective activities of the isolated compounds were preliminarily evaluated, and the results indicated that compounds 2, 5 and 16 possess potent protective effects on -butyl hydroperoxide (-BHP)-induced oxidative injury , and further study revealed that 16 significantly alleviates -BHP-induced hepatotoxicity by effectively improving cell viability and decreasing reactive oxygen species (ROS) generation and the cell apoptosis rate in HepG2 cells.

Four new cassane-type diterpenoids from the seed kernels of Roxb.

The first investigation of chemical composition in seed kernels of Roxb. resulted in the separation of four new cassane diterpenes, including three furanoditerpenes (, and ) and one tricyclic type (). It was the first found cassane diterpenoids from this plant.

Jingshu Keli for treating cervical spondylotic radiculopathy: The first multicenter, randomized, controlled clinical trial.

Background: Jingshu Keli (or Jingshu granules), a traditional Chinese medicine, are widely used for treating cervical spondylotic radiculopathy in China; however, no randomized, double-blind, controlled study has verified their effectiveness.

Purpose: To evaluate the efficacy and safety of Jingshu Keli for the treatment of cervical spondylotic radiculopathy in a randomized controlled trial.

Design: From August 2015 to July 2017, a multicenter, randomized, double-blind, placebo-controlled trial was conducted at 13 large- and medium-sized hospitals in China.