Publications by authors named "Tianli Lu"
Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.
Int J Nanomedicine
December 2024
Introduction: Alopecia is a systemic disease with multiple contributing factors. Effective treatment is challenging when only hair growth mechanisms are targeted while ignoring the role of maintaining hair follicle microenvironment homeostasis, which is crucial for cell growth and angiogenesis. Oxidative stress and inflammation are major disruptors of this microenvironment, leading to inhibited cell proliferation and compromised hair follicle circulation.
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- The study highlights the complexity of alopecia treatment and criticizes current therapies for their single-mechanism and long-term side effects.
- A new water-in-oil microemulsion formulation using Panax notoginseng saponins (PNS ME) improves skin penetration and promotes hair growth by enhancing dermal papilla cell mobility and reducing skin irritation.
- PNS ME shows significant therapeutic outcomes for both telogen effluvium and androgenetic alopecia in mice, with promising safety and efficacy compared to traditional treatments like minoxidil.
Dual tobramycin and docosahexaenoic acid loaded nanoemulsions combating Pseudomonas aeruginosa-induced pulmonary infection.
Colloids Surf B Biointerfaces
October 2024
Article Synopsis
- Pseudomonas aeruginosa forms biofilms that are tough to eliminate and can cause severe lung issues due to inflammation and oxidative stress.
- Researchers created oil-in-water nanoemulsions (TD-αT NEs) that encapsulate the antibiotic tobramycin (TOB) to effectively target these bacterial biofilms and reduce lung damage.
- When inhaled, these TD-αT NEs not only significantly decreased lung bacterial counts and inflammation but also protected against oxidative stress, making them a promising treatment for chronic lung infections.
Wound regeneration with complete functions and skin appendages is still challenging in wound dressing application. Inspired by the efficient wound healing in the fetal environment, we developed a fetal milieu-mimicking hydrogel for accelerating wound healing simultaneously with hair follicle regeneration. To mimic the fetal extracellular matrix (ECM), which contains high content of glycosaminoglycans, hyaluronic acid (HA) and chondroitin sulfate (CS) were selected to fabricate hydrogels.
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- Scientists wanted to see if a special acupuncture treatment could help people who can't swallow well after having a stroke.
- They split 60 patients into two groups: one group got regular therapy and the other group got extra acupuncture along with the regular treatment.
- After 4 weeks, they found that the patients who got the special acupuncture did better by swallowing more easily compared to the regular group!