Associations among environmental unpredictability, changes in resting-state functional connectivity, and adolescent psychopathology in the ABCD study.

Background: Unpredictability is a core but understudied dimension of adversities and has been receiving increasing attention recently. The effects of unpredictability on psychopathology and the underlying neural mechanisms, however, remain unclear. It is also unknown how unpredictability interacts with other dimensions of adversities in predicting brain development and psychopathology of youth.

EEG-Based Emotion Recognition Using an Improved Weighted Horizontal Visibility Graph.

Emotion recognition, as a challenging and active research area, has received considerable awareness in recent years. In this study, an attempt was made to extract complex network features from electroencephalogram (EEG) signals for emotion recognition. We proposed a novel method of constructing forward weighted horizontal visibility graphs (FWHVG) and backward weighted horizontal visibility graphs (BWHVG) based on angle measurement.

Self-Assembled Folic Acid-Targeted Pectin-Multi-Arm Polyethylene Glycol Nanoparticles for Tumor Intracellular Chemotherapy.

Ursolic acid is widely used as an effective anticancer drug for the treatment of various cancers. However, its poor water solubility, short circulation time , and lack of targeting have made it a burden for clinical applications. We report a self-assembled folate-modified pectin nanoparticle for loading ursolic acid (HCPT@F-Pt-PU NPs) and embed the anticancer drug hydroxycamptothecin to achieve synergistic treatment with ursolic acid.