Tuning the Sensitivity of MoS Nanopores: From Labeling to Labeling-Free Detection of DNA Methylation.

DNA methylation discrimination is often challenged by complicated pretreatment, insufficient sensitivity, and suboptimal accuracy. Here, single-molecule readout of DNA methylation is reported using single-layer MoS nanopores. By tuning pore dimension, the sensitivity of MoS nanopores is manipulated, empowering both labeling and labeling-free strategies for DNA methylation discrimination.

Mediated Mendelian randomization analysis to determine the role of immune cells in regulating the effects of plasma metabolites on childhood asthma.

Childhood asthma is a chronic inflammatory disease of the airways, the pathogenesis of which involves multiple factors including genetic predisposition, environmental exposure, and immune system regulation. To date, the causal relationships between immune cells, plasma metabolites, and childhood asthma remain undetermined. Therefore, we aim to utilize the Mendelian randomization approach to assess the causal relationships among immune cells, plasma metabolites, and childhood asthma.

A randomized controlled trial investigating the impact of a single flash cupping session on patients with chronic lower back pain using multichannel surface electromyographic assessment.

Background: Chronic lower back pain (CLBP) is one of the most common disorders worldwide. Flash cupping has the ability to relieve CLBP; nevertheless, its impact on CLBP and the likely mechanism of action have not been studied.

Objective: The goal of this study was to assess the impact of a single, brief cupping session on CLBP and low back muscle activity using multichannel surface electromyography (sEMG).

[Prescription and medication regularity of traditional Chinese medicine for treating child pneumonia based on data mining].

To analyze and summarize formulae of traditional Chinese medicine(TCM) in the treatment of pediatric pneumonia in CNKI based on the data mining method. CNKI was retrieved for literatures of TCM treatment of pneumonia in children in recent 20 years, which was taken the data source. After screening, a prescription database was established.

Complications of retained intraperitoneal gallstones from laparoscopic cholecystectomy.

Laparoscopic cholecystectomy is now the gold standard procedure for the treatment of symptomatic gall bladder stones. Spillage of gall bladder stones into the peritoneal cavity may occur due to inadvertent iatrogenic gall bladder perforation during dissection of the gall bladder. We report a case of a 66 year old woman who had to return to theatre three times over two years to deal with complications from retained intra-peritoneal gallstones that were spilt at her initial laparoscopic cholecystecomy.