Publications by authors named "Tianhua Piao"
Article Synopsis
- Age-related cataract (ARC) is primarily caused by oxidative stress leading to the death of lens epithelial cells, and the antioxidant epigallocatechin gallate (EGCG) from green tea has been shown to reduce this cell death and lens clouding in older mice.
- Transcriptome analysis identified RASSF2 as a key gene influenced by EGCG, with higher levels of RASSF2 linked to ARC in both clinical samples and mouse tissues.
- RASSF2 was found to play a significant role in preventing apoptosis of lens epithelial cells through its regulation of AKT phosphorylation, suggesting a potential targeted treatment approach using EGCG for age-related cataracts.
MiR-433 inhibits retinoblastoma malignancy by suppressing Notch1 and PAX6 expression.
Biomed Pharmacother
August 2016
Retinoblastoma (RB) is the most frequent primary intraocular cancer. It has been demonstrated by previous studies that retinoblastoma is initiated primarily by the inactivation of the retinoblastoma Rb1 gene in retinal cells. However, additional genetic alterations than Rb1 mutation could play important roles in the process of transforming benign retinal cells into retinoblastoma tumor cells.
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