Publications by authors named "Tianheng Xiao"
Reliable molecular biomarkers to predict fertility remain scarce. The current study explored the potential of testis-specific RNAs as biomarkers for male infertility and sperm quality. Using RT-PCR and RT-qPCR assays, we identified seven circular RNAs from the human gene in human sperm.
View Article and Find Full Text PDFThe Drosophila tracheal system is a favorable model for investigating the program of tubular morphogenesis. This system is established in the embryo by post-mitotic cells, but also undergoes remodeling by adult stem cells. Here, we provide a comprehensive cell atlas of Drosophila trachea using the single-cell RNA-sequencing (scRNA-seq) technique.
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- Testis size is influenced by Sertoli cells, with PUMILIO1 (PUM1) and PUMILIO2 (PUM2) proteins playing significant roles in regulating this size through their effects on translation and cell cycle control.* ! -
- Research shows that deleting the Pum1 gene specifically in Sertoli cells leads to smaller testis size, while sperm production and fertility are unaffected. Removing a target gene of PUM1, Cdkn1b, helps restore testis size, indicating the importance of PUM1 in controlling organ size.* ! -
- The study also finds that PUM2 has a similar function, especially when both PUM1 and PUM2 are removed,