Advancements in imaging of intracranial atherosclerotic disease: beyond the arterial lumen to the vessel wall.

Intracranial atherosclerotic disease (ICAD) significantly increases the risk of ischemic stroke. It involves the accumulation of plaque within arterial walls and narrowing or blockage of blood vessel lumens. Accurate imaging is crucial for the diagnosis and management of ICAD at both acute and chronic stages.

Metabolism: an important player in glioma survival and development.

Gliomas are malignant tumors originating from both neuroglial cells and neural stem cells. The involvement of neural stem cells contributes to the tumor's heterogeneity, affecting its metabolic features, development, and response to therapy. This review provides a brief introduction to the importance of metabolism in gliomas before systematically categorizing them into specific groups based on their histological and molecular genetic markers.

Numerical simulation of ultrawideband supercontinuum generation covering a 2-20 µm waveband in cascaded all-soft-glass fiber.

We designed a cascaded all-soft-glass fiber structure and simulate midinfrared 2-20 µm ultrawideband supercontinuum (SC) generation numerically. The cascaded fiber structure consists of a 1.5 m fiber, a 0.

A new species of Gorochov, 1987 from Xizang, China (Orthoptera, Trigonidiidae, Trigonidiinae).

The genus Gorochov, 1987 includes 10 species from Asia, with nine documented in China. In this study, a new species, He, , is described from Xizang, China. Morphologically, it resembles (Chopard, 1932) but can be distinguished by a smaller inner tympanum, dark-brown setae on the 5 segment of the maxillary palp, and a rounded apex on the ectoparamere.

Are the recently described fossil Mole Crickets of Myanmar amber real gryllotalpids? (Orthoptera: Gryllotalpidae & Gryllidae).

We report five new Myanmar amber specimens attributable to "Mole Cricket" †Pherodactylus rectanguli n. comb., hitherto regarded as a Mole Cricket (Orthoptera: Grylloptalpidae).

Adenylate Kinase Fused to Spidroin as a Catalyst for Decreasing Leakage out of 3D-Bioprinted Hydrogels and for ATP Regeneration.

Numerous metabolic reactions and pathways use adenosine 5'-triphosphate (ATP) as an energy source and as a phosphorous or pyrophosphorous donor. Based on three-dimensional (3D)-printing, enzyme immobilization can be used to improve ATP regeneration and operability and reduce cost. However, due to the relatively large mesh size of 3D-bioprinted hydrogels soaked in a reaction solution, the lower-molecular-weight enzymes cannot avoid leaking out of the hydrogels readily.

Active site identification and CO oxidation in UiO-66-XX thin films.

Metal-organic frameworks (MOFs) offer an intrinsically porous and chemically tunable platform for gas adsorption, separation, and catalysis. We investigate thin film derivatives of the well-studied Zr-O based MOF powders to understand their adsorption properties and reactivity with their adaption to thin films, involving diverse functionality with the incorporation of different linker groups and the inclusion of embedded metal nanoparticles: UiO-66, UiO-66-NH, and Pt@UiO-66-NH. Using transflectance IR spectroscopy, we determine the active sites in each film upon consideration of the acid-base properties of the adsorption sites and guest species, and perform metal-based catalysis with CO oxidation of a Pt@UiO-66-NHfilm.

A secretory system for extracellular production of spider neurotoxin huwentoxin-I in .

Due to their advantages in structural stability and versatility, cysteine-rich peptides, which are secreted from the venom glands of venomous animals, constitute a naturally occurring pharmaceutical arsenal. However, the correct folding of disulfide bonds is a challenging task in the prokaryotic expression system like due to the reducing environment. Here, a secretory expression plasmid pSE-G1M5-SUMO-HWTX-I for the spider neurotoxin huwentoxin-I (HWTX-I) with three disulfides as a model of cysteine-rich peptides was constructed.

Construction and validation of an angiogenesis-related gene expression signature associated with clinical outcome and tumor immune microenvironment in glioma.

Glioma is the most prevalent malignant intracranial tumor. Many studies have shown that angiogenesis plays a crucial role in glioma tumorigenesis, metastasis, and prognosis. In this study, we conducted a comprehensive analysis of angiogenesis-related genes (ARGs) in glioma.

Risk Factors of Postoperative Meningitis in Lateral Ventricular Trigone Meningiomas: A Clinical Analysis of 64 Patients.

Purpose: Patients with intraventricular tumors are more susceptible to postoperative meningitis (POM) than other intracranial tumors. In this study, we explored the risk factors of POM in lateral ventricular trigone meningiomas (LVTMs).

Methods: Clinical features of 64 patients with LVTMs were analyzed.

Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients: A case report and review of literature.

Background: The coexistence of meningioma and other intracranial primary benign tumors is rare, especially in non-neurofibromatosis type 2, and there is limited guidance for the management of such patients. Here, we report a series of 5 patients with concomitant meningioma and other intracranial benign tumors, including subependymoma and pituitary adenoma.

Case Summary: Five non-neurofibromatosis type 2 patients with simultaneous occurrence of meningioma and other intracranial benign tumors were retrospectively reviewed.

RODFormer: High-Precision Design for Rotating Object Detection with Transformers.

Aiming at the problem of Transformers lack of local spatial receptive field and discontinuous boundary loss in rotating object detection, in this paper, we propose a Transformer-based high-precision rotating object detection model (RODFormer). Firstly, RODFormer uses a structured transformer architecture to collect feature information of different resolutions to improve the collection range of feature information. Secondly, a new feed-forward network (spatial-FFN) is constructed.

Raspberry Pi-Based Sleep Posture Recognition System Using AIoT Technique.

The relationship between sleep posture and sleep quality has been studied comprehensively. Over 70% of chronic diseases are highly correlated with sleep problems. However, sleep posture monitoring requires professional devices and trained nursing staff in a medical center.

Decreased CD8 Lymphocytic Infiltration in Multifocal and Multicentric Glioblastomas.

Purpose: Multifocal and multicentric glioblastomas (mGBMs) are associated with a poorer prognosis compared to unifocal glioblastoma (uGBM). The presence of CD8 tumor-infiltrating lymphocytes (TILs) is predictive of clinical outcomes in human malignancies. Here, we examined the CD8 lymphocytic infiltration in mGBMs.

MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors.

Mini-chromosome maintenance (MCM) proteins are critical components of DNA-replication-licensing factors. MCM8 is an MCM protein that exhibits oncogenic functions in several human malignancies. However, the role of MCM8 in glioblastomas (GBMs) has remained unclear.

A new species of genus Sichuana from Sichuan, China (Orthoptera: Tettigoniidae: Tettigoniinae).

In this study, we describe one new species, Sichuana feicui He sp. nov., from Mao County, Sichuan Province, China.

Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma: A case report and literature review.

Rationale: Tumor-to-tumor metastasis is a rare clinical phenomenon. Although meningioma is the most common intracranial recipient of cancer metastasis, only a few cases have been reported. We present a case of metastasis of lung adenocarcinoma into intracranial meningioma and review the published literature.

Nonfunctioning pituitary adenomas in pediatric and adolescent patients: a clinical analysis of a series of 14 patients.

Purpose: Nonfunctional pituitary adenomas (NFPAs) in pediatric and adolescent age are extremely rare. This study aimed to report a series of 14 pediatric and adolescent NFPAs to assist in its clinical management.

Methods: A total of 14 consecutive patients pathologically diagnosed with NFPAs (age ≤ 20 years) were retrospectively examined, and the clinical data were analyzed.

A Multimodal Emotional Human-Robot Interaction Architecture for Social Robots Engaged in Bidirectional Communication.

For social robots to effectively engage in human-robot interaction (HRI), they need to be able to interpret human affective cues and to respond appropriately via display of their own emotional behavior. In this article, we present a novel multimodal emotional HRI architecture to promote natural and engaging bidirectional emotional communications between a social robot and a human user. User affect is detected using a unique combination of body language and vocal intonation, and multimodal classification is performed using a Bayesian Network.

MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas.

: Glioblastoma (GBM) is highly proliferative and resistant to radio-chemotherapy. Loss of tumor suppressor gene TP53 function frequently occurs at protein level in GBMs. This inhibition is often mediated by other components within the p53 signaling axis, including MDM2, whose binding protein (MTBP) plays an important role in the regulation of MDM2 and p53 activity.

Comparative analysis of intracranial meningiomas in patients younger than 40 years.

Purpose: Intracranial meningiomas are relatively rare in young adults, and their specific clinical features remain unclear. The authors analyzed the clinical characteristics of intracranial meningioma in patients younger than 40 years.

Methods: Consecutive patients younger than 40 years with meningioma (n = 223) who underwent surgical treatment at our hospital from 2010 to 2018 were retrospectively reviewed.

NFAT1-Mediated Regulation of NDEL1 Promotes Growth and Invasion of Glioma Stem-like Cells.

Glioma stem-like cells (GSC) promote tumor generation and progression. However, the mechanism of GSC induction or maintenance is largely unknown. We previously demonstrated that the calcium-responsive transcription factor nuclear factor of activated T cells-1 (NFAT1) is activated in glioblastomas and regulates the invasion of tumor cells.

Redox Activities of Metal-Organic Frameworks Incorporating Rare-Earth Metal Chains and Tetrathiafulvalene Linkers.

Metal-organic frameworks (MOFs) incorporating lanthanide nodes and tetrathiafulvalene (TTF) linkers offer a viable approach for combining redox activity and magnetism in one material. Four rare-earth lanthanide ions (RE = Tb, Dy, Ho, and Er) were found to form isostructural MOFs consisting of metal chains bridged by redox-active tetrathiafulvalene-tetrabenzoate (TTFTB) whereby the carboxylate moieties act in both anti- anti and syn- syn coordination modes. These materials display tunable redox-active properties and slow magnetic relaxation phenomenon (Er and Dy).

Self-Adaptive Spectrum Analysis Based Bearing Fault Diagnosis.

Bearings are critical parts of rotating machines, making bearing fault diagnosis based on signals a research hotspot through the ages. In real application scenarios, bearing signals are normally non-linear and unstable, and thus difficult to analyze in the time or frequency domain only. Meanwhile, fault feature vectors extracted conventionally with fixed dimensions may cause insufficiency or redundancy of diagnostic information and result in poor diagnostic performance.