Publications by authors named "Tianhao Chen"
Article Synopsis
- - FOXM1 is a crucial transcription factor that helps maintain cellular balance by managing essential processes including cell growth, DNA repair, and responses to stress and drugs.
- - Recent research highlights FOXM1's role in various diseases, particularly in lung conditions, by promoting healing through cell proliferation and regulating inflammation and fibrosis.
- - This review aims to discuss FOXM1's therapeutic potential in treating lung diseases like acute lung injury and asthma, offering new insights for clinical treatment strategies.
Article Synopsis
- Early detection of rice blast disease is crucial for maintaining rice yields, leading to the creation of a specialized dataset focused on the disease's varying lesion characteristics.
- A new object detection model called GCPDFFNet was developed, featuring modules for global context extraction and parallel differentiation to better identify small lesions.
- GCPDFFNet showed significant performance improvements over the existing CenterNet model, increasing detection accuracy from 83.6% to 95.4% while keeping inference speeds suitable for real-time applications.
Evaluating community-embedded elder care: A case study of supply and demand in Hangzhou, China.
J Eval Clin Pract
September 2024
Article Synopsis
- This study focuses on the elder care services in Hemu Community, Hangzhou, and how they adapt to the challenges posed by urbanization and an aging population.
- It employs a mixed-methods approach that includes interviews, observations, and document analysis to evaluate the adequacy and satisfaction with these services.
- The findings reveal that while services generally meet community needs, they face challenges such as content specificity and service visibility, highlighting the necessity for enhanced collaboration among various stakeholders to improve elder care.
Article Synopsis
- - Solid-state batteries require solid electrolytes that have high ionic conductivity and good electrochemical stability, but current polymer-based options are falling short.
- - The research focuses on enhancing lithium-ion conductivity by integrating mesoporous metal-organic frameworks (MOFs) into a polymer matrix, utilizing specially constructed MOFs with pores over 3.0 nm.
- - This approach allows better polymer penetration and lithium salt dissociation, leading to impressive ionic conductivity and lithium transference numbers, ultimately advancing solid-state electrolyte technology.
Article Synopsis
- * A study involving 3,025 hemodialysis patients found that those sleeping more than 7 hours were more likely to face hypertension and high levels of sugar and fats in the blood, while shorter sleep durations also increased risks for some conditions.
- * The research revealed that poor sleep quality had a negative impact on good cholesterol (HDL) and was linked to high triglycerides, with notable differences seen between genders.
Article Synopsis
- Organic scintillators are gaining interest for X-ray detection in sectors like healthcare, but struggle with issues like low efficiency in absorbing X-rays and utilizing triplet excitons.
- The development of new organogold(III) complexes, Tp-Au-1 and Tp-Au-2, incorporates a novel interaction approach that significantly boosts X-ray attenuation and exciton harvesting.
- The Tp-Au-2 complex achieved an exceptional scintillation light yield of 77,600 photons per MeV, leading to high-quality X-ray imaging with excellent spatial resolution, surpassing many existing scintillator materials.
Article Synopsis
- - Thermally activated delayed fluorescence (TADF) emitters with through-space charge transfer (TSCT) show potential for piezochromic luminescent (PCL) materials due to their ability to change properties under pressure! - The structural dynamics of these materials allow for adjustments in charge transfer interactions and stacking arrangements, enabling a full-color emission process that spans 170 nm! - These TSCT-TADF-PCL emitters have a perfect photoluminescence quantum yield and could be useful for applications in X-ray scintillator imaging!
Article Synopsis
- This study aimed to examine how aging and senescent osteocytes impact bone health, specifically in the context of osteoporosis, and to understand the mechanisms behind this process.
- Researchers induced senescence in a specific cell model and found that the resulting conditioned medium and exosomes from senescent cells hindered the differentiation of bone-forming cells (osteoblasts), with microRNA analysis revealing a key miR-494-3p that plays a crucial role.
- In vivo experiments showed that exosomes from senescent osteocytes promoted bone loss in a mouse model, but increasing levels of miR-494-3p could counteract this effect, suggesting potential therapeutic pathways for age-related bone
Article Synopsis
- - Aeration significantly speeds up the secondary compression of municipal solid waste (MSW) in aerobic bioreactors compared to anaerobic ones, based on tests conducted under different stress conditions.
- - The study's results indicates that up to 100% increase in secondary compression rate can be achieved with higher aeration rates, while the steady-state strain also improves but to a lesser extent.
- - Findings highlight that the effectiveness of aeration diminishes with increased stress levels, and specific conditions like higher moisture content and composition (e.g., paper and wood) can further enhance compression characteristics.
Mechanisms of microRNA-132 in central neurodegenerative diseases: A comprehensive review.
Biomed Pharmacother
January 2024
Article Synopsis
- MicroRNA-132 (miR-132) is a key regulatory molecule in the central nervous system (CNS) that shows varying expression levels in neurological disorders, which are linked to disease onset and progression.
- The expression of miR-132 is influenced by several factors, including neuronal development, synaptic changes, inflammation, and cell death.
- Understanding miR-132 better could lead to new diagnostic and treatment methods for CNS diseases, making it an important focus for future clinical research.
Article Synopsis
- - The study investigates how hydrogen sulfide (HS) interacts with iron oxides in petroleum facilities using density functional theory (DFT), focusing on binding preferences and bond changes during adsorption.
- - Results show HS tends to attach to iron sites, causing the S-H bond to lengthen slightly, which leads to its decomposition and formation of products such as sulfur (S), hydroxyl (HO), and iron sulfide (FeS).
- - The analysis identifies two main reaction paths for HS with iron oxides, with one releasing significantly more heat than the other, and concludes that hydrogen sulfide corrosion products easily react to form diverse sulfur-iron compounds, aligning with experimental outcomes.
Article Synopsis
- High-throughput sequencing of amplicons helps accurately identify species and analyze community structures, which is essential for environmental and pathogen monitoring studies.
- Traditional library preparation kits for amplicon sequencing are expensive and time-consuming due to multiple steps, leading to a need for a more efficient method.
- The proposed "one-step PCR approach" simplifies library construction, significantly reduces costs, and demonstrates effective amplification and demultiplexing for reliable species identification, making it applicable to various research fields.
Article Synopsis
- Researchers developed P(DA-Fc) nanoparticles that can redirect GSH's role, allowing it to facilitate ROS production instead of clearing it, thus promoting cancer cell death.
- This approach leverages the unique properties of GSH and PDA-based nanomaterials to enhance CDT's efficiency, marking a significant innovation in cancer treatment strategies.
Article Synopsis
- The study investigates the relationship between aging, dialysis duration, and the control of calcium, phosphorus, and iPTH levels in hemodialysis patients, highlighting that aging is a significant issue in this group.
- Conducted on 3,025 hemodialysis patients in China, the research found that those with poor control of calcium and phosphorus levels, especially those undergoing dialysis for longer periods, showed a disparity between chronological age and biological age.
- The results suggest that improper metabolic control can accelerate aging in hemodialysis patients, indicating the need for further research on the importance of regulating these minerals to potentially slow down the aging process.
Article Synopsis
- Brain stimulation with penetrating electrodes helps treat neurological disorders by activating resident neural precursor cells (NPCs) that can aid in brain repair.
- A new conductive cryogel electrode was designed to enhance NPC activation, featuring a modulus-switching mechanism that ensures better compatibility with brain tissue and reduces mechanical issues during implantation.
- This cryogel electrode is biocompatible, allows for low-voltage stimulation, and has shown significant potential for expanding NPCs, making it a promising alternative for regenerative medicine in enhancing neural repair.
Article Synopsis
- - The study investigates the effectiveness of aerobic exercise (AE) and resistance exercise (RE) in reducing depressive symptoms among cancer survivors, as there's a lack of systematic reviews on this topic.
- - After analyzing 28 randomized controlled trials with nearly 3000 participants, the results indicated that both AE and RE effectively reduced depressive symptoms immediately after treatment but not in the medium term.
- - The findings suggest that AE and RE can help alleviate depressive symptoms in cancer patients, especially with exercise done three times a week, but more research is needed for specific cancer types.
Article Synopsis
- Recent advancements in miniaturized magnetically controlled microgripper tools for robot-assisted surgery mean surgeons lack direct tissue contact, necessitating the use of haptic feedback technologies to minimize tissue trauma.
- A new 9 mm flexible resistive tactile sensor has been designed, utilizing resistivity changes and the piezoresistive effect to enhance feedback during delicate operations.
- The sensor is constructed from low-cost materials, featuring multiple layers and optimized sub-components, achieving sensitivity in the range of 0.04-1.3 N while being flexible and comparable in performance to more expensive alternatives.
Whereas vaccination is established as one of the most effective and available methods against seasonal flu and holds high potential for many infectious diseases, immune response may differ among individuals and regions. In this study we examined the effects of gut microbiota on vaccination with human serum albumin (HSA) as the model vaccine in C57BL/6J mice. We observed that a two-week antibiotic cocktail (ABX) treatment hampered HSA-specific IgG1 in serum, whereas fecal microbiota transplantation (FMT) restored the gut microbiota impaired by the ABX treatment and consequently increased the proportions of macrophages in the mesenteric lymph nodes (MLNs), plasma cells in the peripheral blood, and HSA-specific immunoglobulin G1 (IgG1) in the serum.
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- * The challenge of tuning these particle sizes in real time has been addressed by creating spherical polymeric particles that can swell and contract when exposed to light, thanks to a new polymerization technique.
- * The method involves synthesizing amphiphilic macro-RAFT agents with azobenzene groups to control the polymerization process, allowing uniform submicron particles to change size with UV/visible-light exposure, which enhances the development of RPC materials.
Article Synopsis
- * A new ex vivo stimulation system was developed to test the effectiveness of BPMP, finding that a cathodal amplitude of 200 μA significantly increased the NPC pool and improved their movement.
- * This ex vivo system successfully mirrored the activation of NPCs observed in live mice, providing a more efficient way to optimize electric field parameters for potential real-world applications in brain injury and disease treatment.
Article Synopsis
- A quantum battery made of two-level atoms is studied, focusing on its charging by both harmonic and electrostatic fields.
- The hybrid charging method outperforms traditional harmonic-only charging in battery capacity and power, regardless of atomic interactions.
- Repulsive interactions between atoms enhance battery performance, while attractive interactions hinder capacity and discharge power.
Article Synopsis
- Serum magnesium (Mg) levels are linked to various health issues like insulin resistance and inflammation, and this study aims to explore how Mg relates to allostatic load (AL) in hemodialysis patients.
- Conducted in Anhui Province, China, the research involved 3,025 hemodialysis patients, ultimately including 1,222 in the analysis, revealing that 23.4% had high AL levels.
- Findings indicate that lower serum Mg is associated with higher odds of high AL, suggesting that maintaining higher Mg levels could lower health risks for these patients, warranting further research.
Article Synopsis
- This study investigates the link between childhood blood eosinophils and various types of allergic diseases, focusing on asthma, rhinitis, and dermatitis.
- Researchers analyzed blood counts and IgE test results from over 5,000 children aged 0-13, utilizing advanced statistical models to explore these relationships.
- Findings showed that higher eosinophil levels were associated with increased risk of allergic asthma and rhinitis, especially in school-aged children, while lower eosinophil levels correlated with non-allergic conditions.