Publications by authors named "Tianhao Ba"
Article Synopsis
- The study aimed to determine if postprandial hypoglycaemia is a distinct and consistent type of glucose metabolism issue and to identify genetic factors related to it.
- Researchers analyzed data from a large metabolic disease database, focusing on individuals with abnormal glucose levels after an oral glucose tolerance test (OGTT) and compared them to a control group.
- Results showed a small number of participants with significant hypoglycemia had mutations in a gene called PEG3, suggesting a possible genetic link, but the authors recommend further research to confirm and expand these findings.
Objective: Gain-of-function (GOF) variants of KCNJ11 cause neonate diabetes and maturity-onset diabetes of the young (KCNJ11-MODY), while loss-of-function (LOF) variants lead to hyperinsulinemia hypoglycemia and subsequent diabetes. Given the limited research of KCNJ11-MODY, we aimed to analyse its phenotypic features and prevalence in Chinese patients with early-onset type 2 diabetes (EOD).
Design, Patients And Measurements: We performed next-generation sequencing on 679 Chinese EOD patients to screen for KCNJ11 exons variants.
Article Synopsis
- Metformin, insulin, and insulin secretagogues do not change HbA1c levels in patients with glucokinase maturity-onset diabetes of the young (GCK-MODY), with the effectiveness of newer drugs still being unclear.
- A case study over 8 years demonstrated that various oral glucose-lowering medications did not improve HbA1c levels in a patient with GCK-MODY.
- The glucokinase activator dorzagliatin was found to be both effective and safe, suggesting it may be a promising treatment for GCK-MODY.
Glucokinase variant-induced maturity-onset diabetes of the young (GCK-MODY) exhibits the unique clinical features of mild fasting hyperglycemia. However, formal studies of its glucose excursion pattern in daily life in comparison with those with or without other types of diabetes are lacking. We conducted a case-control study including 25 patients with GCK-MODY, 25 A1C-matched, drug-naive patients with type 2 diabetes (T2DM), and 25 age-, BMI-, and sex-matched subjects with normal glucose tolerance (NGT).
View Article and Find Full Text PDFFew studies have investigated the dose-response relationship between exercise and weight control. This study aimed to assess the effects of different types of supervised exercise training on weight control and other metabolic outcomes in patients with type 2 diabetes mellitus and explore the dose-response relationship between exercise volume/duration and these outcomes. PubMed/MEDLINE, Embase, and Cochrane databases were searched for studies between January 1980 and June 2019.
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