Gelatin methacryloyl microneedle loaded with 3D-MSC-Exosomes for the protection of ischemia-reperfusion.

Exosomes (Exo) generated from mesenchymal stem cells (MSCs) have great therapeutic potential in ischemia-reperfusion treatment. For best therapeutic effect, high quality Exo product and effective delivery system are indispensable. In this study, we developed a new strategy for ischemia-reperfusion recovery by combining MSCs 3D (3D-MSC) culturing technology to generate Exo (3D-MSC-Exo) and microneedle for topical delivery.

Low-temperature construction of MoS quantum dots/ZnO spheres and their photocatalytic activity under natural sunlight.

Zinc oxide (ZnO) nanophotocatalyst is a promising candidate for degrading organic pollutants but has an extremely low photocatalytic activity under nature sunlight. In this work, flower-like MoS quantum dots/ZnO (MQ/ZnO) nanospheres with the size of approximately 1.26 μm are prepared at low temperature.

[Experimental study on anti-pancreatic cancer effect of oridonin].

Objective: To investigate the apoptotic effect of oridonin in human pancreatic cancer cells PANC-1, and to explore the underlying mechanism.

Methods: MTT assay was used to measure the cell viability. Apoptosis was determined by confocal laser scanning microscope after Hoechst 33342 staining and flow cytometry analysis after PI staining.