Publications by authors named "Tiange Yao"
The small G protein Arf1 has been identified as playing a selective role in supporting cancer stem cells (CSCs), making it an attractive target for cancer therapy. However, the current Arf1 inhibitors have limited translational potential due to their high toxicity and low specificity. In this study, two new potent small-molecule inhibitors of Arf1, identified as DU101 and DU102, for cancer therapy are introduced.
View Article and Find Full Text PDFProduction of 2,6-dihydroxybenzoic acid (2,6-DHBA) via enzymatic carboxylation of resorcinol by decarboxylases is of great promising but shows depressed equilibrium conversion. In this study, 2,3-dihydroxybenzoic acid decarboxylase from Aspergillus oryzae (2,3-DHBD_Ao) pushing the conversion towards carboxylation for efficient 2,6-DHBA biosynthesis was achieved. Meanwhile, a novel amino-modified and lignin-doped cellulose nanocrystal aerogel (A-LCNCA) with high specific surface area and prominent CO capture was prepared for 2,3-DHBD_Ao immobilization.
View Article and Find Full Text PDFTumor immunotherapy has achieved breakthroughs in a variety of tumors. However, the systemic absence of T cells in tumors and immunosuppressive tumor microenvironment so far limits the efficacy of immunotherapy to a small population of patients. Therefore, novel agents to increase T-cell tumor infiltration are urgently needed in the clinic.
View Article and Find Full Text PDFArticle Synopsis
- Incompatibility group C (IncC) plasmids are concerning due to their ability to carry and spread antibiotic resistance genes from animals to humans, posing a public health threat.
- A study characterized 20 IncC plasmids from food-producing animals in China, identifying four as type 1, 15 as type 1/2 hybrids, and one as type 2, further classifying hybrids into subtypes based on genetic differences.
- The research revealed that these plasmids showed a variety of genetic mutations and rearrangements, particularly involving insertion sequences, contributing to their structural diversity and ability to resist multiple antibiotics.
Article Synopsis
- * Researchers sequenced EG81 using advanced technologies, identified multiple antimicrobial resistance genes, and found significant genetic information including a chromosome and two plasmids in its genome.
- * The findings highlight the presence of the optrA resistance gene and suggest that this strain poses a significant public health risk due to its combined resistance to vancomycin and other antibiotics.
Objectives: To characterize the MDR genomic islands (GIs) in Proteus mirabilis isolates.
Methods: Two P. mirabilis strains (C55 and C74) of chicken origin were subjected to WGS (HiSeq and PacBio) and the MDR GIs were determined.
Objectives: The aim of this study was to characterise the whole genome sequence of linezolid-intermediate Enterococcus hirae strain CQP3-9 isolated from a large-scale swine farm in Sichuan Province, China, in August 2018.
Methods: An Illumina MiSeq platform (400-bp paired-end reads with 230-fold average coverage) and PacBio RS II sequencing instrument (100-fold average read depth) were used for genome sequencing. The chromosome and two plasmids were assembled using the software SMRT portal v.