The Domain Name System (DNS) is a fundamental component of the internet, responsible for resolving domain names into IP addresses. DNS servers are typically categorized into four types: recursive resolvers, root name servers, Top-Level Domain (TLD) name servers, and authoritative name servers. The latter three types of servers store actual records, while recursive resolvers do not store any real data and are only responsible for querying the other three types of servers and responding to clients.
View Article and Find Full Text PDFTo evaluate the cost-effectiveness of dabrafenib plus trametinib combination therapy versus vemurafenib as first-line treatment in patients with BRAF V600 mutation-positive unresectable or metastatic melanoma from a healthcare system perspective in China. This study employed a partitioned survival model with three health states (progression-free survival, post-progression survival and dead) to parameterize the data derived from Combi-v trial and extrapolated to 30 years. Health states' utilities were measured by EQ-5D-3L, also sourced from the Combi-v trial.
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