Delayed macular development in preterm infants with spontaneously regressed retinopathy of prematurity.

Purpose: To evaluate the macular development in preterm infants with spontaneously regressed retinopathy of prematurity (ROP) utilizing handheld spectral domain optical coherence tomography (SD-OCT) during the early postnatal period.

Design: A cross-sectional observational study.

Methods: Using handheld SD-OCT, OCT images were acquired in non-sedated infants ages about 37 weeks(w) post-menstrual-age (PMA = gestational age in weeks + chronological age).

Metformin combined with cisplatin reduces anticancer activity via ATM/CHK2-dependent upregulation of Rad51 pathway in ovarian cancer.

Ovarian cancer (OC) is the deadliest malignancy of the female reproductive system. The standard first-line therapy for OC involves cytoreductive surgical debulking followed by chemotherapy based on platinum and paclitaxel. Despite these treatments, there remains a high rate of tumor recurrence and resistance to platinum.

Design and simulation of a compact polarization beam splitter based on dual-core photonic crystal fiber with elliptical gold layer.

For the polarization multiplexing requirements in all-optical networks, this work presents a compact all-fiber polarization beam splitter (PBS) based on dual-core photonic crystal fiber (PCF) and an elliptical gold layer. Numerical analysis using the finite element method (FEM) demonstrates that the mode modulation effect of the central gold layer effectively reduces the dimensions of the proposed PBS. By determining reasonable structural parameters of the proposed PCF, the coupling length ratio (CLR) between X- and Y-polarized super-modes can approach 2, achieving a minimal device length of 0.

The relationship between depression and lipid accumulation product: a population-based study.

Background: Lipid Accumulation Product (LAP) is a new type of obesity index. The relationship between LAP and depression is unclear, and this cross-sectional study was conducted to explore the relationship between LAP and depression using the National Health and Nutrition Examination Survey (NHANES) database from 2005-2018.

Methods: In our study, logistic regression analysis was used to calculate the odds ratio between depression and LAP, and subgroup analysis and sensitivity analysis were also performed to verify the robustness of the results.

Single-test Ritchey-Common interferometry.

The Ritchey-Common test is widely adopted to measure large optical flats. The traditional Ritchey-Common test eliminates the defocus error with multiple tests by changing the position of the mirrors, which suffers from cumbersome steps, poor repeatability, coupled system error, extra mirror deformation, and potential overturning. The above problems increase the test time, decrease the reliability and accuracy, increase the test cost, and threaten manufacturing safety.

Highly Breathable, Stretchable, and Tailorable TPU Foam for Flexible Gas Sensors.

Continuous real-time monitoring of air quality is of great significance in the realms of environmental monitoring, personal safety, and healthcare. Recently, flexible gas sensors have gained great popularity for their potential to be integrated into various smart wearable electronics and display devices. However, the development of gas sensors with superior sensitivity, breathability, and stretchability remains a challenge.

Deep-Growing Neural Network With Manifold Constraints for Hyperspectral Image Classification.

In the absence of sufficient labels, deep neural networks (DNNs) are prone to overfitting, resulting in poor performance and difficulty in training. Thus, many semisupervised methods aim to use unlabeled sample information to compensate for the lack of label quantity. However, as the available pseudolabels increase, the fixed structure of traditional models has difficulty in matching them, limiting their effectiveness.

Toxic effect window of ovarian development in female offspring mice induced by prenatal prednisone exposure with different doses and time.

Background: Prednisone is one of the most used synthetic glucocorticoids during pregnancy. Epidemiological investigations suggested that prenatal prednisone therapy could affect fetal development, but systematic studies on its effects on ovarian development and the "toxic effect window" remained scarce.

Methods: In this study, by simulating clinical application characteristics, Kunming mice were given prednisone by oral gavage with different doses (0.

SIRT3 ameliorates polycystic ovary syndrome through FOXO1/PGC-1α signaling pathway.

Background: Current studies have shown that Sirtuin3 (SIRT3) plays a key role in oocyte maturation. Polycystic ovary syndrome (PCOS) is a common disease caused by endocrine and metabolic abnormalities. The specific regulatory role and mechanism of SIRT3 in PCOS have not been reported.

A Semi-Analytical Method for Designing a Runner System of a Multi-Cavity Mold for Injection Molding.

Multi-cavity mold design is an efficient approach to achieving mass production and is frequently used in plastic injection applications. The runner system of a multi-cavity mold delivers molten plastic to each cavity evenly and makes the molded product from each individual cavity possess an equivalent quality. Not only the dimensions, but also the invisible quality, e.

Transient Early Fine Motor Abnormalities in Infants Born to COVID-19 Mothers Are Associated With Placental Hypoxia and Ischemia.

Long-term effects of Coronavirus Disease 2019 (COVID-19) on infants born to infected mothers are not clear. Fine motor skills are crucial for the development of infant emotional regulation, learning ability and social skills. Clinical information of 100 infants born to 98 mothers (COVID-19 = 31, non-COVID-19 = 67) were collected.

Bisphosphine-Stabilized Gold Nanoclusters with the Crown/Birdcage-Shaped Au Cores: Structures and Optical Properties.

To estimate the effect of bisphosphine ligands on the formation of the isomeric core structures of gold nanoclusters, the different ligation of bisphosphine ligands is usually used to participate in the construction of gold nanoclusters. Here, the selection of the different bisphosphine ligands, DPEphos and Xantphos, is performed to construct two novel gold nanoclusters, [Au(DPEphos)Cl]Cl () and [Au(Xantphos)Cl]Cl(), which have been characterized by IR, H and P NMR, ESI-MS, XRD, SEM, XPS, TG, UV-vis, and X-ray crystal structure analysis. The structural analyses indicate that the ligation of bisphosphine ligands play a crucial role in the formation of the fascinating Au cores: gold nanocluster includes a birdcage-shaped Au core with eight electrons, while gold nanocluster contains a crown-shaped Au core with eight electrons.

A Dynamic Multiobjective Evolutionary Algorithm Based on Decision Variable Classification.

In recent years, dynamic multiobjective optimization problems (DMOPs) have drawn increasing interest. Many dynamic multiobjective evolutionary algorithms (DMOEAs) have been put forward to solve DMOPs mainly by incorporating diversity introduction or prediction approaches with conventional multiobjective evolutionary algorithms. Maintaining a good balance of population diversity and convergence is critical to the performance of DMOEAs.

Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes.

B-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonist, we determined that B-32 behaved as a typical Ab2β based on a series of enzyme-linked immunosorbent assay assays. The results of fluorescence-activated cell sorting, indirect immunofluorescence and competitive receptor binding assays demonstrated that B-32 specifically binds to the GHR expressed on target cells.

Differential intracellular signalling properties of the growth hormone receptor induced by the activation of an anti-GHR antibody.

A series of studies have reported that anti-GHR antibody can function as a GHR agonist and may serve as an attractive tool for studying the mechanisms of GHR activation. However, to date, there is relatively little information about intracellular signalling triggered by anti-GHR antibody. Therefore, in this work, we have developed a panel of monoclonal antibodies to GHBP, among which one Mab, termed CG-172, was selected for further characterisation because of its signalling properties.