Gold-coated tilted fiber Bragg gratings for lead ion sensing.

Surface plasmon resonance sensor based on gold-coated tilted fiber Bragg gratings (SPR-TFBGs) are perfectly suited for fine refractometry. Thanks to the functionalization of the gold layer, they can be used for label-free biosensing. They have been largely used for the specific detection of proteins and cells.

Partially gold-coated tilted FBGs for enhanced surface biosensing.

To date, there is clear experimental evidence that gold-coated tilted fiber Bragg gratings (TFBGs) are highly sensitive plasmonic biosensors that provide temperature-compensated detection of analytes at concentrations in the picomolar range. As most optical biosensors, they bring an evanescent wave in the surrounding medium, which makes them sensitive to both surface refractive index variations (= the useful biosensing signal) and to bulk refractive index changes (= the non-useful signal for biosensing). This dual sensitivity makes them prone to drift.

MiRNA-543 promotes osteosarcoma cell proliferation and glycolysis by partially suppressing PRMT9 and stabilizing HIF-1α protein.

Osteosarcoma (OS) is the most common primary bone tumor, occurring frequently in adolescents and possessing a high malignant severity. MicroRNAs play critical roles during OS development. Thus, elucidation of the involvement of specific microRNAs in the development of OS may provide novel therapeutic targets for OS treatment.