Objective: To investigate the significance of PAX8-PPAR expression in thyroid cancer and the application of a PAX8-PPAR-targeted ultrasound contrast agent in the early diagnosis of thyroid cancer.
Methods: In this study, the expression of PAX8-PPAR in thyroid cancer tissues, paracancer groups, and normal thyroid tissues was detected by western and immunohistochemical techniques; the effects of PAX8-PPAR expression inhibition on thyroid cancer cell growth, clonogenic ability, and antiapoptosis were examined. The terminal carboxylactic acid/hydroxyacetic acid copolymer (PLGA-COOH) nanoparticles were prepared by the double emulsification solvent volatilization method.
The number of patients with lung cancer is difficultly diagnosed in the early stage. The purpose of the study was to investigate the effects of CT- and ultrasound-guided percutaneous transthoracic needle biopsy combined with serum CA125 and CEA on the diagnosis of lung cancer. 120 patients with suspected lung cancer admitted to our hospital from January 2019 to January 2020 were selected and divided into an ultrasound group ( = 60) and CT group ( = 60), according to different percutaneous transthoracic needle biopsy modalities.
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