Synopsis of recent research by authors named "Tianbao Lu"
- Tianbao Lu's recent research focuses on the development of small-molecule inhibitors targeting critical proteins involved in cancer and thrombosis, with specific emphasis on BCL6 and Factor XIa as therapeutic targets for non-Hodgkin lymphoma and anticoagulation respectively.
- Lu's studies have highlighted the significance of protein interactions and structural modifications in enhancing the efficacy and bioavailability of cancer therapies, particularly through novel approaches such as exploiting nonclassical interactions and optimizing structure-activity relationships.
- Additionally, Lu has investigated the role of specific proteins, such as BCL10 and thioredoxin 1, in cancer progression and rheumatoid arthritis, uncovering distinct mutation-based dependencies that could guide precision therapy and elucidating mechanisms of inflammation and angiogenesis associated with the disease.
