The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms.

Purpose: There has been interest in determining whether lid wiper epitheliopathy (LWE) plays a key role in causing ocular discomfort. Conflicting reports have made it difficult to discern whether LWE is more prevalent in certain populations, what characteristics are associated with its severity, and what its role is in symptomology. This cross-sectional study on a large and diverse population attempts to answer these questions.

Increased corneal epithelial permeability after overnight sleep.

Purpose: To investigate factors of ethnicity, sex, age, and diurnal variation on human corneal epithelial permeability.

Methods: Data of corneal epithelial permeability to sodium fluorescein (Pdc) were collected from 374 noncontact lens wearers at various times after awakening throughout the day. Mixed-effect models were developed to investigate the association between Pdc and factors of interest, including time awake (TA), age, sex, ethnicity, and interactions of these factors.