Ultrasonic-assisted preparation of two-dimensional materials for electrocatalysts.

Developing green, environmental, sustainable new energy sources is an important problem to be solved in the world. Among the new energy technologies, water splitting system, fuel cell technology and metal-air battery technology are the main energy production and conversion methods, which involve three main electrocatalytic reactions, hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR). The efficiency of the electrocatalytic reaction and the power consumption are very dependent on the activity of the electrocatalysts.

The trends of psychosomatic symptoms and perceived stress among healthcare workers during the COVID-19 pandemic in China: Four cross-sectional nationwide surveys, 2020-2023.

An unseen wave of vast infection was detected in China in December 2022, and healthcare workers faced inevitable challenges and heavy stress. We aimed to present a dynamic mental health map and, most importantly, provide a timely report of the current situation in healthcare workers. The current study conducted four national cross-sectional online surveys from February and March 2020, Apr 2022, and Jan 2023.

Direction- and polarization-tunable spontaneous emission beneficial from diffraction orders of a square R6G-nanopore array.

To meet the miniaturization and compatibility of current micro-nano optical devices, two-dimensional (2D) photonic crystals (PCs), which can manipulate the optical parameters and their propagation with more degree of freedom, have become more important in nano optics. In the case of 2D PCs, the specific symmetry of the microscopic lattice arrangement determines its macroscopic optical properties. In addition, beyond this key element of lattice arrangement, the unit cell of PCs is also a critical factor in modulating the far-field optical behaviors.

Development and validation of a nomogram for predicting the risk of immediate postoperative deep vein thrombosis after open wedge high tibial osteotomy.

Purpose: This study aimed to identify independent risk factors for immediate postoperative deep vein thrombosis (DVT) in patients with open wedge high tibial osteotomy (OWHTO) and to develop and validate a predictive nomogram.

Methods: Patients who underwent OWHTO for knee osteoarthritis (KOA) from June 2017 to December 2021 were retrospectively analyzed. Baseline data and laboratory test results were collected, and the occurrence of DVT in the immediate postoperative period was regarded as the study outcome event.

Characterization and Coexpression Analysis of the Family Genes in Related to Leaf Development.

TIFYs are plant-specific transcription factors that contain the TIFY structural domain and play an important role in plant leaf growth and development. However, the role played by TIFY in ( Salisb.) leaf development has not been investigated.

Organic Polarized Light-Emitting Transistors.

Electrically driven polarized light-emitting sources are central to various applications including quantum computers, optical communication, and 3D displays, but serious challenges remain due to the inevitable incorporation of complex optical elements in conventional devices. Here, organic polarized light-emitting transistors (OPLETs), a kind of novel device that integrates the functions of organic field-effect transistors, organic light-emitting diodes, and polarizers into one unique device, are demonstrated with a degree of polarization (DOP) as high as 0.97, which is comparable to completely linearly polarized light (DOP = 1).

Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity.

Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are implicated in balancing goal-directed and habitual control over actions and show disruption in disorders with compulsive, inflexible behaviors, including AUD. However, whether there is a causal link between disrupted premotor activity and altered action control is unknown.

Flexible aluminum-doped hafnium oxide ferroelectric synapse devices for neuromorphic computing.

The HfO-based ferroelectric tunnel junction has received outstanding attention owing to its high-speed and low-power characteristics. In this work, aluminum-doped HfO (HfAlO) ferroelectric thin films are deposited on a muscovite substrate (Mica). We investigate the bending effect on the ferroelectric characteristics of the Au/Ti/HfAlO/Pt/Ti/Mica device.

Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1.

Hematopoietic progenitor kinase 1 (HPK1), a member of mitogen-activated protein kinase kinase kinase kinase (MAP4K) family of Ste20 serine/threonine kinases, is a negative regulator of T-cell receptor (TCR) signaling. Inactivating HPK1 kinase has been reported to be sufficient to elicit antitumor immune response. Therefore, HPK1 has attracted much attention as a promising target for tumor immunotherapy.

Activated reprograms neural progenitor cells to glioma stem cell‑like phenotype.

Glioma is the most common primary brain tumor. Glioma stem cells (GSCs) are the origin of gliomagenesis and may develop from normal neural progenitor cells (NPCs). However, how neoplastic transformation occurs in normal NPCs and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear.

Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination.

Background And Aims: In the course of clinical practice, hepatic ischemia/reperfusion (I/R) injury is a prevalent pathophysiological event and is caused by a combination of complex factors that involve multiple signaling pathways such as MAPK and NF-κB. USP29 is a deubiquitinating enzyme important during the development of tumors, neurological diseases, and viral immunity. However, it is unknown how USP29 contributes to hepatic I/R injury.

A Dual Heat Shock Protein Down-Regulation Strategy Using PDA/Cu/ICG/R Controlled by NIR "Switch" Enhances Mild-Photothermal Therapy Effect.

The purpose of this study is to down-regulate heat shock proteins and improve the mild photothermal therapy (mild-PTT) effect of polydopamine (PDA) by preparing the nanosystem of Cu and indocyanine green (ICG)-loaded PDA nanospheres with surface modification of integrin-targeted cyclic peptide (cRGD) (PDA/Cu/ICG/R), which can limit ATP synthesis through the double mitochondrial destruction pathway. In vitro and in vivo experiments using PDA/Cu/ICG/R irradiated with an NIR laser demonstrate that when NIR is "OFF," Cu can undergo Fenton-like reaction in tumor cells, producing a large amount of hydroxyl radicals (·OH), which leads to oxidative stress in cells. This oxidative stress can cause mitochondrial oxidative phosphorylation dysfunction, resulting in limited ATP synthesis.

Cisplatin attenuates taste cell homeostasis and induces inflammatory activation in the circumvallate papilla.

Gustation is important to several biological functions in mammals. However, chemotherapy drugs often harm taste perception in cancer patients, while the underlying mechanism is still unclear for most drugs and there is no effective way to restore taste function. This study investigated the effects of cisplatin on the taste cell homeostasis and gustatory function.

Lithium recovery and solvent reuse from electrolyte of spent lithium-ion battery.

Great progresses have been made in recovering valuable metals or regenerating materials from spent lithium-ion batteries (LIBs), but how to treat the spent electrolyte and recover its valuable components economically are still a bottleneck. In this study, the volatile organic solvents (dimethyl carbonate (DMC) and diethyl carbonate (DEC)) in spent electrolyte were recycled through vacuum distillation based on thermodynamic analysis and reused for LIBs. The recovery efficiencies of DMC and DEC reach almost 100% and 79.

Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 M).

The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a great threat to public health while various vaccines are available worldwide. Main protease (M) has been validated as an effective anti-COVID-19 drug target. Using medicinal chemistry and rational drug design strategies, we identified a quinazolin-4-one series of nonpeptidic, noncovalent SARS-CoV-2 M inhibitors based on baicalein, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one.

Ultrasound-Assisted Adsorption of Perchlorate Using Calcined Hydrotalcites and the Thermal Stabilization Effect of Recycled Adsorbents on Poly(vinyl chloride).

Due to their high anion exchange and memory effect, the layered double hydroxides (LHDs) have wide applications for some areas. In this work, an efficient and green recycling route for layered double hydroxide based adsorbents is proposed specifically for application as a poly(vinyl chloride) (PVC) heat stabilizer without requiring secondary calcination. Conventional magnesium-aluminum hydrotalcite was synthesized using the hydrothermal method followed by removal of carbonate anion (CO) between LDH layers by calcination.

Association of preoperative nutritional status evaluated by the controlling nutritional status score with walking independence at 180 days postoperatively: a prospective cohort study in Chinese older patients with hip fracture.

Background: Malnutrition is significantly associated with unfavorable outcomes, but there is little high-level evidence to elucidate the association of malnutrition with losing walking independence (LWI) after hip fracture surgery. This study aimed to assess the association between preoperative nutritional status evaluated by the Controlling Nutritional Status (CONUT) score and walking independence at 180 days postoperatively in Chinese older hip fracture patients.

Methods: This prospective cohort study included 1958 eligible cases from the SSIOS database.

Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold.

Discovery of small-molecule inhibitors against programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) axis provides a promising alternative to overcome the inevitable defects of PD-1/PD-L1 monoclonal antibodies (mAbs). Here, we report a series of indanes as novel small-molecule inhibitors of PD-1/PD-L1 interaction. Thirty-one indanes were synthesized and the structure-activity relationships (SARs) demonstrated that conformational restriction with (S)-indane is superior in potency to inhibit the interaction of PD-1 and PD-L1.

Enhanced soil function and health by soybean root microbial communities during remediation of Cd-contaminated soil with the application of soil amendments.

The interactions between soil microbiomes at various trophic levels are essential for restoring soil functions. Legumes are considered as "pioneer crops" in degraded or contaminated soils because they can fix nitrogen through symbiotic relationships with rhizobacteria, which promotes soil fertility. However, little is known about the abilities of legumes to contribute to the health of soil contaminated with cadmium (Cd).

Multilegged matter transport: A framework for locomotion on noisy landscapes.

Whereas the transport of matter by wheeled vehicles or legged robots can be guaranteed in engineered landscapes such as roads or rails, locomotion prediction in complex environments such as collapsed buildings or crop fields remains challenging. Inspired by the principles of information transmission, which allow signals to be reliably transmitted over "noisy" channels, we developed a "matter-transport" framework that demonstrates that noninertial locomotion can be provably generated over noisy rugose landscapes (heterogeneities on the scale of locomotor dimensions). Experiments confirm that sufficient spatial redundancy in the form of serially connected legged robots leads to reliable transport on such terrain without requiring sensing and control.

Prediction of total knee replacement using deep learning analysis of knee MRI.

Current methods for assessing knee osteoarthritis (OA) do not provide comprehensive information to make robust and accurate outcome predictions. Deep learning (DL) risk assessment models were developed to predict the progression of knee OA to total knee replacement (TKR) over a 108-month follow-up period using baseline knee MRI. Participants of our retrospective study consisted of 353 case-control pairs of subjects from the Osteoarthritis Initiative with and without TKR over a 108-month follow-up period matched according to age, sex, ethnicity, and body mass index.

Temporal and clonal characterization of neural stem cell niche recruitment in the medaka neuromast.

Stem cell populations are defined by their capacity to self-renew and to generate differentiated progeny. These unique characteristics largely depend on the stem cell micro-environment, the so-called stem cell niche. Niches were identified for most adult stem cells studied so far, but we know surprisingly little about how somatic stem cells and their niche come together during organ formation.