Study on eccentric compressive performance of circular double skin concrete filled steel tube connected by thread through inside lining tube.

Connection method of lengthening the steel tube of circular hollow sandwich concrete-filled steel tube by inside lining tube and thread is proposed. Twelve circular hollow sandwich concrete filled steel tubular beam-column connected by thread through inside lining tube are designed and fabricated using the length of the thread along the axial direction, the working height of the thread, and the position of the thread as parameters; In addition, one unconnected specimen and two welded specimens also are designed and fabricated to conduct controlled experimental research. The test phenomena and failure modes, axial compressive load-compression curve, axial compressive load-lateral deflection curve, and axial compressive load-strain in steel tube curve, as well as bearing capacity, strength reservation, deflection curve shape, lateral stiffness, ductility and plane section assumption are analyzed.

Cadmium in Market Pork Kidneys: A Study on Cadmium Bioavailability and the Health Effects Based on Mouse Models.

Edible offal of farmed animals can accumulate cadmium (Cd). However, no studies have investigated Cd bioavailability and its health effects. Here, based on mouse models, market pork kidney samples exhibited high Cd relative bioavailability of 74.

GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development.

Introduction: Osteoarthritis (OA) is the most common arthritis that is characterized by the progressive synovial inflammation and loss of articular cartilage. Although GYY4137 is a novel and slow-releasing hydrogen sulfide (HS) donor with potent anti-inflammatory properties that may modulate the progression of OA, its underlying mechanism remains unclear.

Objectives: In this study, we validated the protective role of GYY4137 against OA pathological courses and elucidated its underlying regulatory mechanisms.

Percutaneous lordoplasty for the treatment of severe osteoporotic vertebral compression fractures with kyphosis.

Objective: The study aimed to explore the safety and effectiveness of percutaneous lordoplasty (PLP) in the treatment of severe osteoporotic vertebral compression fracture (OVCF).

Methods: Included in this prospective study were patients with single-segment acute severe OVCF who were treated with PLP in our institution from July 2016 to October 2019. Patients' back pain and quality of life were assessed using the visual analog scale (VAS) and SF-36 scores.

Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis.

Osteoarthritis (OA) is the most common degenerative joint disease in the world. Gene therapy based on delivering microRNAs (miRNAs) into cells has potential for the treatment of OA. However, the effects of miRNAs are limited by the poor cellular uptake and stability.

Isolation, purification and PEG-mediated transient expression of mesophyll protoplasts in Camellia oleifera.

Background: Camellia oleifera (C. oleifera) is a woody edible oil crop of great economic importance. Because of the lack of modern biotechnology research, C.

TRPV6 is a potential regulator of bone resorption in bone loss induced by estrogen deficiency.

The precise effect of estrogen (E2) on osteoclast function is still poorly understood. The aim of this study was to investigate the potential role of transient receptor potential vanilloid 6 (TRPV6) in E2-mediated osteoclast function and to characterize the relevant underlying mechanisms. Here, we found that Trpv6 is drastically decreased in ovariectomy operation animals and the administration of E2 results in an increased expression of Trpv6 in osteoclasts.

Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation.

Osteoarthritis (OA) is one of the most frequent chronic joint diseases with the increasing life expectancy. The main characteristics of the disease are loss of articular cartilage, subchondral bone sclerosis and synovium inflammation. Physical measures, drug therapy and surgery are the mainstay of treatments for OA, whereas drug therapies are mainly limited to analgesics, glucocorticoids, hyaluronic acids and some alternative therapies because of single therapeutic target of OA joints.

CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-α in Postmenopausal Osteoporosis.

Tumor necrosis factor-alpha (TNF-α) promotes osteoclasts differentiation to enhance bone resorption and inhibits osteoblasts differentiation to impair bone formation, which plays a central role in the development of postmenopausal osteoporosis (PMOP). Recent studies implicated an important role of circular RNAs (circRNAs) in osteoporosis. The purpose of this study is to investigate whether circRNAs might be implicated in TNF-α-regulated osteoclasts differentiation and osteoblasts differentiation in PMOP.

Hydrogen sulfide is a novel regulator implicated in glucocorticoids-inhibited bone formation.

Glucocorticoids contribute to the increased incidence of secondary osteoporosis. Hydrogen sulfide (HS) is a gasotransmitter and plays an essential role in bone metabolism. In this study, we investigated the therapeutic effects of HS on glucocorticoid-induced osteoporosis (GIO).

Hydrogen sulphide promotes osteoclastogenesis by inhibiting autophagy through the PI3K/AKT/mTOR pathway.

Hydrogen sulphide (HS), a gasotransmitter, plays an important role in the regulation of bone homeostasis. However, the precise effect of HS on osteoclasts was still elusive. The goal of this study was to determine the potential role of HS in regulation of osteoclasts and the underlying mechanisms by which HS affected osteoclastogenesis.

Regulation of TRPV5 transcription and expression by E2/ERα signalling contributes to inhibition of osteoclastogenesis.

The increasing of osteoclasts formation and activity because of oestrogen (E2) deficiency is very important in the aetiology of postmenopausal osteoporosis. Our previous studies showed that E2 inhibited osteoclastic bone resorption by increasing the expression of Transient Receptor Potential Vanilloid 5 (TRPV5) channel. However, the exact mechanism by which E2 increases TRPV5 expression is not fully elucidated.

Resveratrol Attenuates Lipopolysaccharides (LPS)-Induced Inhibition of Osteoblast Differentiation in MC3T3-E1 Cells.

BACKGROUND LPS-inhibited osteoblastic differentiation plays an important role in the pathogenesis of osteomyelitis. Thus, searching for drugs that affect LPS-mediated osteoblastic differentiation may be crucial in developing therapies for osteomyelitis. The purpose of this study was to investigate the role and mechanisms of resveratrol, a natural polyphenol present in red wine, on LPS-inhibited osteoblastic differentiation.

Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.

Transient receptor potential vanilloid (TRPV) channels function to maintain the dynamic balance of calcium signaling and calcium metabolism in bones. The goal of this study was to determine the potential role of TRPV6 in regulation of chondrocytes. The level of TRPV6 expression was analyzed by western blot in articular cartilage derived from the knee joints of osteoarthritis (OA) rat models and OA patients.

Treatment of pelvic fractures through a less invasive ilioinguinal approach combined with a minimally invasive posterior approach.

Background: Unstable pelvic fractures usually result from high-energy trauma. There are several treatment modalities available. The purpose of this study was to evaluate the clinical application of a new less invasive ilioinguinal approach combined with a minimally invasive posterior approach technique in patients with unstable pelvic fractures.

Early molecular responses of bone to estrogen deficiency induced by ovariectomy in rats.

Objective: The study was performed to investigate bone deteriorations and the molecular responses of bone to early estrogen deficiency induced by ovariectomy (OVX) in rats.

Methods: The female rats were subjected to OVX (4 or 8 week) and sham (4 or 8 week) operation. All rats were killed 4 week or 8 week after the surgical operation.

Effect and mechanism of Salicornia bigelovii Torr. plant salt on blood pressure in SD rats.

In this paper, the effect and mechanism of Salicornia bigelovii Torr. plant salt (SPS) on blood pressure in Sprague Dawley (SD) rats were investigated. The results showed that the edible salt induced hypertension, but the SPS did not.

Lumbar pedicle cortical bone trajectory screw.

Objective: The purpose of this study was to demonstrate the lumbar pedicle cortical bone trajectory (CBT) screw fixation technique, a new fixation technique for lumbar surgery.

Data Sources: The data analyzed in this review are mainly from articles reported in PubMed published from 1994 to 2014.

Study Selection: Original articles and critical reviews relevant to CBT technique and lumbar pedicle fixation were selected.

Comparison of the outcome of early and delayed surgical treatment of complete acromioclavicular joint dislocation.

Purpose: The aim of this study is to compare the clinical and radiographic results and the complication rate between early and delayed surgical treatment of acromioclavicular joint (ACJ) dislocation.

Methods: Publications in the management of ACJ dislocation are identified from the PubMed database between January 1993 and December 2013 using "acromioclavicular joint" and "dislocation" as keywords. The eligibility criteria included are as follows: (1) ACJ dislocation; (2) intervention, early compared with delayed surgical treatment or the surgical treatment for acute compared with chronic ACJ dislocation; (3) human; and (4) English articles.

Multistrand titanium cable for the coracoclavicular stabilization of acute acromioclavicular joint dislocation.

The aim of this retrospective study was to evaluate the outcome of the surgical treatment of acute complete acromioclavicular (AC) joint dislocation with multistrand titanium cable for coracoclavicular (CC) stabilization. Forty-two patients with acute complete AC joint dislocation, Rockwood III, IV, V, were treated with CC stabilization using multistrand titanium cable. Thirty-nine patients could be evaluated after a mean follow-up period of 42 months (range, 34-60).

An osteotomy anterolateral approach for lateral tibial plateau fractures merged with relatively simple and intact posterolateral corner displacement.

Introduction: This study investigates the safety and efficacy of anterolateral (AL) osteotomy for the treatment of lateral tibial plateau fractures merged with relatively simple and intact posterolateral (PL) corner displacement and screens applicable patients.

Methods: Totally, 11 patients with lateral tibial plateau fractures involving the PL corner were included in this study. Of them, seven patients sustained their injuries from motor vehicle accidents (MVAs), three from sports and one from fall from height.

Knockout of TRPV6 causes osteopenia in mice by increasing osteoclastic differentiation and activity.

Background: Calcium ion (Ca(2+)) signals are required for osteoclast differentiation. Previous study showed that transient receptor potential vanilloid 5 (TRPV5) is an essential Ca(2+) transporter in osteoclastogenesis and bone resorption. TRPV5 and TRPV6 represent two highly homologous members within the transient receptor potential (TRP) superfamily.