Building Bilayer MoS with Versatile Morphologies via Etching-And-Growth Coexisting Method.

The etch-engineering is a feasible avenue to tailor the layer number and morphology of 2D layered materials during the chemical vapor deposition (CVD) growth. However, less reports strengthen the etch-engineering used in the fabrication of high-quality transition metal dichalcogenide (TMD) materials with tunable layers and desirable morphologies to improve their prominent performance in electronic and optoelectronic devices. Here, an etching-and-growth coexistence method is reported to directly synthesize high-quality, high-symmetric MoS bilayers with versatile morphologies via CVD.

Ultrahigh Energy Storage Performance in BiFeO-Based Lead-Free Ceramics via Tuning Structural Homogeneity and Domain Engineering Strategies.

Lead-free ceramic-based dielectric capacitors are critical in electronics and environmental safety. Nevertheless, developing ideal lead-free ceramics with excellent energy storage properties remains a challenging task for practical applications. Herein, the enhanced relaxation behavior and increased breakdown electric field are utilized to realize the high energy storage behavior of (0.

Genetic Analyses of Flower, Fruit, and Stem Traits of Intergeneric Hybrids Between 'Honghuagqinglong' and 'Heilong' Pitayas.

Pitaya is renowned for its delicious taste, high nutritional value, and economic as well as ornamental appeal. Breeding new pitaya varieties can boost economic returns by appealing to consumers with diverse morphological traits. However, the genetic basis underlying key traits in intergeneric hybrids of pitaya has yet to be fully understood.

Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice.

Endothelial dysfunction, characterized by a decline in endothelial physiological functions, is a significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), a key member of Ca-permeable channels, plays a crucial role in maintaining vascular functions. However, the role and mechanisms of TRPV4 in aging-related endothelial dysfunction remain incompletely understood.

Automated LA-DBD-TLC-MS device for accurate detection of biogenic amines in fishery products coupled with machine learning algorithms.

A novel, compact, and automated laser ablation dielectric barrier discharge thin layer chromatography-mass spectrometry (LA-DBD-TLC-MS) device was developed for the rapid detection of biogenic amines (BAs) in fishery products. This plug-and-play system integrates thermal desorption via diode laser, DBD plasma ionization, and tandem MS detection, with key operational parameters optimized through experimental and computational methods. Utilizing nanoscale carbon black as a matrix, the device achieved a detection limit of 0.

Clinical value of serum miRNA-206 in pulmonary tuberculosis.

Objective: This study sought to investigate the diagnostic value and the effect of microRNA (miR)-206 on drug resistance in pulmonary tuberculosis (TB) patients.

Methods: This study included 88 TB patients (TB group) as study subjects, 80 healthy subjects as control 1 (Control group), and 85 latent TB infection (LTBI) patients as control 2 (LTBI group). The drug resistance of TB patients after standard anti-TB treatment was recorded.

Efficient Biotransformation of Icariin to Baohuoside I Using Two Novel GH1 β-Glucosidases.

(EF) is a traditional Chinese herbal medicine, and its primary bioactive ingredients, such as icariin, are flavonoid glycosides. A rare EF flavonoid, baohuoside I, exhibits superior bioactivities and enhanced bioavailability compared to its metabolic precursor icariin. The biotransformation of icariin to baohuoside I can be effectively and specifically achieved by β-glucosidases.

Association of long-term exposure to air pollutants with sensory impairment in middle-aged and elderly adults: a nationwide study in China.

Few studies have examined the impact of ambient air pollutants on sensory impairments (SI) in adults. Using a nationally representative study of 13,505 participants from 125 Chinese cities, we investigated the association of air pollutants with SI among middle-aged and elderly adults. The SI were evaluated by self-reported visual impairment (VI) and/or hearing impairment.

Platelet Activation-Induced In Situ Trapping Metastatic Tumor Cells Strategy for Post-Surgery Tumor Recurrence Immunochemotherapy.

The reasons for the high recurrence and metastasis after triple-negative breast cancer (TNBC) surgery are the potential presence of micrometastases and disseminated tumor cells in the circulation, as well as the immunosuppressive microenvironment caused by the surgery. To address these issues, this work proposed a platelets (PLTs) based hydrogel delivery system for immuno-chemotherapy, (IL-12+NP-PLT)@dAlg. To utilize the targeting ability of PLTs toward tumor cells and maintain the activity of PLTs, doxorubicin-loaded nanoparticles (NP) were attached on the surface of PTLs (NP-PLT).

Factors Influencing Poststroke Cognitive Dysfunction: Cross-Sectional Analysis.

Background: Poststroke cognitive impairment (PSCI) is a common and debilitating complication that affects stroke survivors, impacting memory, attention, and executive function. Despite its prevalence, the factors contributing to PSCI remain unclear, with limited insights into how demographic and clinical variables influence cognitive outcomes.

Objective: This study investigates the incidence of cognitive impairment in patients with stroke and examines key demographic and clinical factors, such as age, gender, and education level, which contribute to cognitive decline.

Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice.

Background And Purpose: Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications and lacks a definitive cure. Both pneumoconiosis and idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics. Because pirfenidone and nintedanib are approved to treat IPF, their potential efficacy as antifibrotic agents in advanced silicosis deserves further exploration.

Immunogenicity and safety of two-dose or three-dose regimens of inactivated COVID-19 vaccines in patients with pulmonary tuberculosis: a randomised clinical trial.

Background: To assess the immunogenicity and safety of two-dose regimen of inactivated COVID-19 vaccines in patients with pulmonary tuberculosis (PTB) and explored the potential benefits of additional dose.

Research Design And Methods: In total, 182 PTB patients were randomly (1:1) assigned to the standard-dose group to receive three standard doses of inactivated COVID-19 vaccines, or the double-dose boosting group to receive two standard doses plus a double dose, with a 28-day interval. Forty healthy controls were assigned to receive two doses of inactivated COVID-19 vaccines 28 days apart.

Microbial Dynamics and Pathogen Control During Fermentation of Distiller Grains: Effects of Fermentation Time on Feed Safety.

Determining the effects of fermentation duration on the microbial ecosystem, potential pathogenic risks, and metabolite generation during the fermentation of distilled grains is essential for safeguarding the safety and enhancing the nutritional profile of animal feed. This study investigates the effect of varying fermentation times (9, 30, and 60 days) on microbial diversity, pathogenic risk, and metabolite profiles in distiller grains using 16S rDNA sequencing and LC-MS-based metabolomics. The results showed that early fermentation (9-30 days) enhanced the abundance of beneficial bacteria, such as and ( < 0.

Protease activated receptor 2 deficiency retards progression of abdominal aortic aneurysms by modulating phenotypic transformation of vascular smooth muscle cells via ERK signaling.

Abdominal aortic aneurysm (AAA) is characterized by localized structural deterioration of the aortic wall, leading to progressive dilatation and rupture. Protease activated receptor 2 (PAR2) dependent signaling has been implicated in the pathophysiology of atherosclerosis through the regulation of smooth muscle cell function. However, its role in AAA remains unclear.

pH responsive and zwitterionic micelle for enhanced cellular uptake and antitumor performance.

The side effects of small molecule chemotherapeutic drugs (SMCD) have brought great pain to the cancer patients. Many nanodrug carriers can relieve the shortcomings of SMCD, but they have complex synthesis processes and lack biodegradability. To overcome both problems, we synthesized a pH responsive biodegradable zwitterionic molecules (EK-D) by linking zwitterionic polypeptide (EK7) and dodecyl acrylate through a simple click reaction.

Unveiling the Role of Strong Metal-Support Interactions in Gold-Catalyzed CO Oxidation on MnO Polymorphs.

The effectiveness of gold (Au)-based catalysts in CO oxidation is significantly influenced by strong metal-support interactions with surface oxygen structures, the mechanisms of which remain elusive. To investigate this property, we selected γ-MnO, featuring Mn(-O-)Mn and Mn-O-Mn structural motifs, and β-MnO, characterized by Mn-O-Mn linkages, as support materials. The CO oxidation process was investigated by fabricating Au nanoparticles supported on these two MnO polymorphs.

Structure-Based Training: A Training Method Aimed at Pixel Errors for a Correlation-Coefficient-Based Neural Network.

In research on building a one-shot learning neural network without pre-training using mass data, the limitation on the information obtained from a single training sample downgrades the performance of the network. In order to improve performance and take full advantage of the support set, in this study, we design three kinds of shadow nodes and propose a structure-based training method for a correlation-coefficient-based neural network. This training strategy focuses on branches that are not activated or inactivated as expected.