Subcutaneous adipose tissue/neutrophil-to-lymphocyte ratio is a potential biomarker in patients with hepatocellular carcinoma undergoing liver resection.

Objective: Both subcutaneous adipose tissue (SAT) and neutrophil-to-lymphocyte ratio (NLR) are associated with the prognosis of hepatocellular carcinoma (HCC). Subcutaneous adipose tissue is an immunonutritional indicator, and NLR reflects the inflammatory status. The purpose of this study was to ascertain the validity of SAT/NLR as potential prognostic biomarkers in HCC patients who are undergoing liver resection.

Combined Bone Mineral Density (BMD) and Monocyte-to-Lymphocyte Ratio (MLR) Predicts Recurrence and Prognosis in Hepatocellular Carcinoma Patients Following Liver Resection.

Background: Bone mineral density (BMD) and monocyte-to-lymphocyte ratio (MLR) were recently identified as novel risk factors for patients with several malignancies. The objective of this study was to validate the role of preoperative BMD/MLR as a potential prognostic biomarker in patients with hepatocellular carcinoma (HCC) undergoing liver resection.

Methods: This investigation enrolled 442 adult patients diagnosed with HCC who underwent liver resection.

Ultra-Low Alginate-Based Multifunctional Composite Binders for Enhanced Mechanical, Electrochemical, and Thermal Performance of Li-S Batteries.

The practical application of Li-S batteries, which hold great potential as energy storage devices, is impeded by various challenges, such as capacity degradation caused volume change, polysulfide shuttling, poor electrode kinetics, and safety concerns. Binder plays a crucial role in suppressing volume change of cathode side, thereby enhancing the electrochemical performance of Li-S batteries. In this research, a novel network binder (SA-Co-PEDOT) composed of sodium alginate is presented, Co ions as cross-linking agent and PEDOT as an electronic conductor.

CD36-mediated accumulation of MDSCs exerts abscopal immunosuppressive responses in hepatocellular carcinoma after insufficient microwave ablation.

The immune landscape of distant unablated tumors following insufficient microwave ablation (iMWA) in hepatocellular carcinoma (HCC) remains to be clarified. The objective of this study is to define the abscopal immune landscape in distant unablated tumor before and after iMWA for HCC. Two treatment-naive patients were recruited for tumor tissue sampling, of each with two HCC lesions.

Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.

We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1.

Copy number variations contribute to malignant tumor development in children with serious birth defects.

There are two key signatures of pediatric cancers: (a) higher prevalence of germline alterations and (b) heterogeneity in alteration types. Recent population-based assessments have demonstrated that children with birth defects (BDs) are more likely to develop cancer even without chromosomal anomalies; therefore, explorations of genetic alterations in children with BDs and cancers could provide new insights into the underlying mechanisms for pediatric tumor development. We performed whole-genome sequencing (WGS) on blood-derived DNA for 1556 individuals without chromosomal anomalies, including 454 BD probands with at least one type of malignant tumor, 757 cancer-free children with BDs, and 345 healthy individuals, focusing on copy number variation (CNV) analysis.

Widespread mercurous [Hg(I)] species in mercury droplet impacted environments: Evidence from an abandoned Hg smelting plant in Xunyang, China.

Mercury (Hg) emissions from Hg smelting (roasting HgS ores) and artisanal small-scale gold mining predominantly include elemental Hg, in either liquid [Hg(0)] or gaseous [Hg(0)] form. The oxidation of Hg(0) into Hg(I) is the first step during Hg(0) oxidation, which enables Hg to enter the food web. However, this oxidation process remains poorly understood, particularly in Hg(0)/Hg(0)-impacted environments.

Causal Brain Network Predicts Surgical Outcomes in Patients With Drug-Resistant Epilepsy: A Retrospective Comparative Study.

Network neuroscience, especially causal brain network, has facilitated drug-resistant epilepsy (DRE) studies, while surgical success rate in patients with DRE is still limited, varying from 30%  ∼  70 %. Predicting surgical outcomes can provide additional guidance to adjust treatment plans in time for poorly predicted curative effects. In this retrospective study, we aim to systematically explore biomarkers for surgical outcomes by causal brain network methods and multicenter datasets.

Roundup induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation.

Unlabelled: Roundup, a glyphosate-based herbicide widely used in agriculture, has raised concerns regarding its potential impact on human health due to the detection of its residues in human urine and serum. Granulosa cells are essential for oocyte growth and follicle development. Previous research has shown that Roundup could affect steroid synthesis, increases oxidative stress, and induces apoptosis in granulosa cells.

The potassium puzzle: exploring the intriguing connection to albuminuria.

Background: Studies have revealed a relationship between dietary potassium intake and albuminuria, despite the fact that the human body needs a lot of potassium. Our study concentrated on the link between dietary potassium intake and albuminuria.

Methods: This study used subgroup analysis and weighted multivariate regression analysis.

Synergistic Effect of InO/NC-CoO Interface on Enhancing the Redox Conversion of Polysulfides for High-Performance Li-S Cathode Materials at Low Temperatures.

Lithium-sulfur (Li-S) batteries are considered as a promising energy storage technology due to their high energy density; however, the shuttling effect and sluggish redox kinetics of lithium polysulfides (LiPSs) severely deteriorate the electrochemical performance of Li-S batteries. Herein, we report a novel configuration wherein InO and CoO are incorporated into N-doped porous carbon as a sulfur host material (InO@NC-CoO) using metal-organic framework-based materials to synergistically tune the catalytic abilities of different metal oxides for different reaction stages of LiPSs, achieving a rapid redox conversion of LiPSs. In particular, the introduction of N-doped carbon improved the electron transport of the materials.

A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy.

Objectives: Epilepsy and migraine are common chronic neurological disease. Epidemiologic studies and shared pathophysiology and treatment suggest that these two diseases overlap. However, migraine is often underestimated among patients with epilepsy.

Attention deficit hyperactivity disorder in children with epilepsy: a multicenter cross-sectional analysis in China.

Background: The diagnosis and treatment of attention deficit hyperactivity disorder (ADHD) comorbid with epilepsy have been insufficiently addressed in China. We conducted a study in China to investigate the current status, diagnosis, and treatment of ADHD in children to further our understanding of ADHD comorbid with epilepsy, strengthen its management, and improve patients' quality of life.

Methods: We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August 2022.

Cellular senescence mediates hexavalent chromium-associated lung function decline: Insights from a structural equation Model.

There is sufficient evidence suggesting that exposure to hexavalent chromium [Cr(VI)] can cause a decline in lung function and the onset of lung diseases. However, no studies have yet explored the underlying mechanisms of these effects from various perspectives such as systemic inflammation, oxidative stress, and cellular senescence, simultaneously. This cross-sectional study was conducted among 304 workers engaged in chromate production and processing in China.

Systematic Analysis of the Relationship Between Elevated Zinc and Epilepsy.

Previous studies have indicated a potential relationship between zinc and epilepsy. The aim of this study is to investigate the causal relationship between zinc, zinc-dependent carbonic anhydrase, and gray matter volume in brain regions enriched with zinc and epilepsy, as well as explore the possible mechanisms by which zinc contributes to epilepsy. First, this study assessed the risk causality between zinc, carbonic anhydrase, and gray matter volume alterations in zinc-enriched brain regions and various subtypes of epilepsy based on Two-sample Mendelian randomization analysis.

Nanorod InO@C Modified Separator with Improved Adsorption and Catalytic Conversion of Soluble Polysulfides for High-Performance Lithium-Sulfur Batteries.

The shuttle effect of soluble lithium polysulfides (LiPSs) poses a crucial challenge for commercializing lithium-sulfur batteries. The functionalization of the separator is an effective strategy for enhancing the cell lifespan through the capture and reuse of LiPSs. Herein, a novel InO nanorod with an ultrathin carbon layer (InO@C) was coated on a polypropylene separator.

Traditional Chinese medicine treats ulcerative colitis by regulating gut microbiota, signaling pathway and cytokine: Future novel method option for pharmacotherapy.

Background: Ulcerative colitis (UC) is a chronic non-specific inflammatory disease with intestinal tract as the main site. The pathogenic of UC has not yet been clarified, and multiple mechanisms can lead to the pathogenesis of UC. Traditional Chinese medicine (TCM) offers an opportunity for UC treatment.

Lower serum AMH concentration is correlated with serum IgG1 decreased in the infertile woman: A real-world retrospective study.

Objectives: In this real-world approach, we examined the serum Anti-Mullerian Hormone (AMH) level and the relationship with serum IgG subclass in the infertile women.

Methods: A total of 574 female participants were recruited for this study. The serum AMH, IgG subclass(IgG1, IgG2, IgG3, IgG4) and immunoglobulin (Ig) G、IgM、IgA、IgE as well as complement C, C were analyzed.