[Effects of arsenic trioxide on human coronary smooth muscle cells: experiment in vitro].

Objective: To study the apoptotic effects of arsenic trioxide on human coronary smooth muscle cells (HCSMCs).

Methods: HCSMCs were cultured and randomly divided into 5 groups to be treated by arsenic trioxide of the concentrations 1.0, 2.

[Relationship between plasma asymmetrical dimethylarginine and coronary artery disease].

Objective: To investigate whether the plasma asymmetrical dimethylarginine (ADMA) level correlates with the extent and severity of coronary atherosclerosis.

Methods: 110 consecutive patients undergoing coronary angiography were divided into five groups according to the result thereof: control group (n = 22, with normal coronary artery), mild coronary artery disease (CAD) group (n = 21, with stenosis < 50% of the major coronary arteries), single branch CAD group III (n = 22, with stenosis >/= 50% of one major coronary artery); double branch CAD group IV (n = 23, with stenosis >/= 50% of two major coronary arteries); and multi-branch CAD group (n = 22, with significant stenosis >/= 50% of more than two major coronary arteries or companies with stenosis of left major coronary). ELISA was used to detect the plasma ADMA.

[Expression of amyloid beta protein and amyloid precursor protein after focal brain ischemia in human].

Objective: To observe the expression of amyloid beta precursor protein and amyloid beta protein in neurons of hippocampal CA1 region after brain ischemia in human.

Methods: Neuronal damage was examined by using HE staining, and expression of APP and Abeta(1-40) was determined by immunohistochemistry in the hippocampal CA1 region of the brain specimens of 43 patients who died 2 h-6 h, 7 h-24 h, 25 h-48 h, 49 h-72 h, 73 h-96 h, 97 h-144 h, or 145 h-168 h after cerebral ischemia and in 2 specimens of patients who died of other diseases as control group.

Results: The expression of Abeta(1-40) was 25.

[Effect of arsenic trioxide on rabbit vascular smooth muscle cells after balloon angioplasty].

Objective: To study the apoptotic effect of arsenic trioxide on rabbit vascular smooth muscle cells (RVSMCs) after balloon angioplasty.

Methods: A New Zealand rabbit underwent balloon angioplasty three times at one of its iliac arteries. The iliac artery at the opposite side was used as control.