Publications by authors named "Tian-yi Zhang"

Proximal femoral fractures in children are challenging in clinical treatment due to their unique anatomical and biomechanical characteristics. The distribution and characteristics of fracture lines directly affect the selection of treatment options and prognosis. Pediatric proximal femur fractures exhibit distinctive features, with the distribution and characteristics of the fracture line playing a crucial role in deciding optimal treatment.

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In this issue of Cell Host & Microbe, Wu et al. identified enriched gut Aspergillus tubingensis in patients with polycystic ovary syndrome (PCOS). In mice, this fungus induced a PCOS-like phenotype by inhibiting interleukin (IL)-22 secretion from ILC3s via the AT-C1-AhR axis.

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In dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis, DPPX antibodies from serum and CSF target the extracellular subunit of the voltage-gated potassium channel 4.2. This targeting leads to a characteristic clinical triad comprising gastrointestinal symptoms (predominantly diarrhea), cognitive-psychiatric dysfunction, and manifestations of CNS hyperexcitability, with hyperekplexia being a more specific feature.

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Alzheimer's disease (AD) is recognized as the leading cause of dementia, imposing a significant economic toll on society. Despite the emergence of novel therapeutic approaches for AD, their efficacy and safety mandates further validation through rigorous clinical trials. In this context, hypertension (HTN) has garnered considerable attention as an amendable risk factor for AD.

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Herpes simplex virus-2 encephalitis (HSV2E) in immunocompetent adults is exceptionally rare, and the subsequent onset of autoimmune encephalitis after HSV2E is even less common. This report presents the inaugural Chinese case of anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) induced by HSV2E, confirmed via metagenomic next-generation sequencing (mNGS). The patient demonstrated a favorable response to intravenous immunoglobulin (IVIG) monotherapy.

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  • Sepsis is a serious infection that can cause multiple organ failures, particularly affecting kidney function, leading to renal injury.
  • The study tested a compound called H-151, which showed promise in improving kidney function in septic mice by reducing harmful substances and inflammation.
  • H-151 also increased the survival rates of mice with sepsis and reduced kidney cell death, suggesting it could be a potential treatment for septic kidney injury and may assist in understanding related biological pathways.
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In conventional chromatographic ligand screening, underperforming ligands are often dismissed. However, this practice may inadvertently overlook potential opportunities. This study aims to investigate whether these underperforming ligands can be repurposed as valuable assets.

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Background: Yiqi Peiyuan (YQPY) prescription, a composite prescription of traditional Chinese medicine, has been used to prevent or delay the continued deterioration of renal function after acute kidney injury (AKI) in some institutions and has shown considerable efficacy.

Objective: This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with AKI.

Design, Setting, Participants And Interventions: This is a prospective, double-blind, multicenter, randomized, and placebo-controlled clinical trial.

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  • Candidalysin, a toxin produced by Candida albicans, plays a crucial role in how the fungus causes disease, but its specific interactions with human proteins were not well understood until now.
  • Researchers used a high-throughput method to identify potential human protein targets of eight Ece1 peptides, discovering that CCNH, which is involved in DNA damage repair, interacts with candidalysin.
  • Candidalysin was found to increase the formation of double-strand DNA breaks by activating CCNH, disrupting the DNA repair pathway, which highlights how this fungal toxin may help the fungus persist in infections.
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Background: The complexity of left ventricular (LV) trabeculae is related to the prognosis of several cardiovascular diseases.

Purpose: To evaluate the prognostic value of LV trabecular complexity in patients with end-stage renal disease (ESRD).

Study Type: Prospective outcome study.

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As the representative item of environmental chemical carcinogen, MNNG was closely associated with the onset of Gastric cancer (GC), while the underlying mechanisms remain largely unknown. Here, we comprehensively analyzed the potential clinical significance of METTL3 in multiple GC patient cohorts. Additionally, we demonstrated that long-term exposure to MNNG elevated METTL3 and EMT marker expression by in vitro and in vivo models.

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Solenopsis invicta is a main issue in southern China and is causing significant damage to the local ecological environment. The extensive use of insecticides has resulted in the development of tolerance in S. invicta.

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  • Existing mercury whole-cell biosensors (WCBs) struggle to detect ultratrace mercury levels needed for environmental safety, which poses risks to human health through the food chain.
  • Researchers developed an improved WCB by evolving the sensing module to respond to ultratrace mercury, achieving a detection limit of 0.313 ng/L and also identifying methylmercury at 98 ng/L.
  • They incorporated a green fluorescent protein for easier detection, allowing visual confirmation of mercury presence at low concentrations and enabling analysis via mobile phone imaging, resulting in a highly sensitive and efficient detection method for real-world applications.
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  • This study wanted to find out if a special measurement (called fractal dimension, or FD) of heart structure can help predict heart problems in patients with kidney issues (end-stage renal disease, or ESRD).
  • They looked at 104 people who had heart scans (MRI) and found that those with more complex heart structures had a higher risk of developing heart failure.
  • The researchers concluded that measuring this heart complexity (FD) could help doctors understand which ESRD patients might be at greater risk for serious heart problems in the future.
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Background: Left ventricular global function index (LVGFI) integrates LV volumetric and functional parameters. In patients with end-stage renal disease (ESRD), cardiac injury manifests as LV hypertrophy and dysfunction. However, the prognostic value of LVGFI in this population remains unclear.

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Tumor mRNA vaccines have been developed for over 20 years. Whether mRNA vaccines could promote a clinical benefit to advanced cancer patients is highly unknown. PubMed and Embase were retrieved from January 1, 2000 to January 4, 2023.

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  • The study investigates the link between tissue stiffness in donor kidneys and poor outcomes in transplant recipients, highlighting how conditions like glomerulosclerosis affect this stiffness.
  • Ultrasound elastography, specifically shear wave elastography (SWE), is used to noninvasively assess kidney stiffness as a potential prognostic tool.
  • Results show that including SWE measurements in patient assessments can enhance risk evaluation and improve management strategies for kidney transplant recipients.
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Background: Vertical run-length nonuniformity (VRLN) is a texture feature representing heterogeneity within native T1 images and reflects the extent of cardiac fibrosis. In uremic cardiomyopathy, interstitial fibrosis was the major histological alteration. The prognostic value of VRLN in patients with end-stage renal disease (ESRD) remains unclear.

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Methane has shown protective effects on a variety of diseases. Among these, neurological diseases have attracted much attention. However, there are many different indicators and application methods of methane in the treatment of neurological diseases.

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Background: The lack of randomized evidence makes it difficult to establish reliable treatment recommendations for patients with M2 occlusion. This study aims to compare the efficacy and safety of endovascular treatment (EVT) with best medical management (BMM) in patients with M2 occlusion, and to investigate whether the optimal treatment varies according to stroke severity.

Methods: Comprehensive literature retrieval was conducted to identify studies that directly compared the outcomes of EVT and BMM.

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Unlabelled: Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAA) and eradicating malignant cells. Here, we present a cancer vaccination approach utilizing myeloid-lineage reprogramming to directly convert cancer cells into tumor-reprogrammed antigen-presenting cells (TR-APC). Using syngeneic murine leukemia models, we demonstrate that TR-APCs acquire both myeloid phenotype and function, process and present endogenous TAAs, and potently stimulate TAA-specific CD4+ and CD8+ T cells.

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Based on the structural features of both succinate dehydrogenase inhibitors (SDHIs) and targeted covalent inhibitors, a series of -phenylpropiolamides containing a Michael acceptor moiety were designed to find new antifungal compounds. Nineteen compounds showed potent inhibition activity on nine species of plant pathogenic fungi. Compounds and showed higher activity on most of the fungi than the standard drug azoxystrobin.

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  • The study aimed to analyze salivary peptide profiles in patients with periodontitis (PD) and chronic obstructive pulmonary disease (COPD) to identify potential biomarkers for diagnosis and treatment.
  • Involved methods included collecting saliva samples from PD patients, PD patients with COPD, and healthy controls, followed by advanced mass spectrometry techniques for peptide profiling.
  • Results showed 10 peptides with significant expression differences between PD patients and those with both PD and COPD, suggesting specific peptides may serve as biomarkers for these conditions.
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