Successful treatment of Kimura's disease with leflunomide and methylprednisolone: a case report.

Kimura's disease (KD) is an uncommon, chronic inflammatory disease characterized by tumor-like lesions in the soft tissue and lymph nodes and increased peripheral blood eosinophil counts and serum immunoglobulin E (IgE). Prednisone is widely used to treat the disease. Here, we reported a 59-year-old KD patient failed to response to prednisone.

[Comparative study on pathology of non involuting congenital hemangioma and infantile hemangioma].

Objective: To distinguish non involuting congenital hemangioma (NICH) and infantile hemangioma (IH) by comparing the pathological structure and marker antigen expression.

Methods: From Jan. 2005 to Aug.

[The distribution and evolution of pericytes in infantile hemangioma].

Objective: To investigate the distribution, phenotype and development of pericytes in infantile hemangioma.

Methods: Fifty-two infantile hemangioma samples were included in our study. alpha-SMA was used as the marker antigen to observe the distribution of pericytes.

[The expression and role of glucose transporter-1 in infantile hemangioma].

Objective: To investigate the expression and role of glucose transporter-1 (Glut1) in infantile hemangioma.

Methods: Fifty-two samples from infantile hemangioma, 25 in cavernous venous malformation, 9 in arteriovenous malformation, 2 in capillary malformation and 5 in normal skin samples were involved in this study. The EnVision immunohistochemical stain was used to investigate the expression of Glut1 protein in these samples.

[The modified sternal elevation for pectus excavatum].

Objective: To improve sternal elevation for pectus excavatum to be more simple, less injured and less recurrent.

Methods: We modified procedures for the sternal elevation for pectus excavatum by dispersal of the shortened fibrous bundle connection with central tendon of the diaphragm, correction of the reverse angle of sternocostales joins, transverse cuneiform anterior osteotomy of sternum and reconnection of oblique resected costal cartilage.

Results: Since March 1997, 8 children (4 - 10-year-old) with the pectus excavatum have been treated by this modified sternal elevation, 4 of them who suffer from quick heart pulse improved their heart rate immediately during the operation, all patients have less bleeding and good cosmetic appearance without any complications.

[33 cases of craniofacial clefts: experience in diagnosis and treatment with tessier classification].

Objective: To introduce our experience in diagnosis and treatment of 33 patients with Tessier craniofacial clefts.

Methods: 33 patients with craniofacial clefts were classified by Tessier classification. According to the type and severity of the clefts, various techniques, from simple local flap transfer to complicated osteotomy and bone grafting were used to correct the deformity in 29 patients.

[The expression and role of Fas/FasL in infantile hemangioma].

Objective: To investigate the expression of Fas/FasL in infantile hemangiomas and discuss the role of Fas/FasL in the pathologic evolution of infantile hemangioma.

Method: The EnVision immunohistochemical stain and RT-PCR technique was used to examine the expression of Fas/FasL protein and mRNA in the infantile hemangiomas.

Results: (1) In the early and middle proliferating stage, a number of infantile hemangioma cells expressed Fas.

An innovation in the subcutaneous island pedicle flap for cutaneous reconstruction.

The aim of this study was to describe an innovation of the transposition pedicle island flap for reconstruction of the medium-sized skin defects in the face, neck and hand. Twenty-seven cases of skin tumours and scars were surgically excised and reconstructed with this island flap. ALL flap survived with primary healing postoperatively.

Subcutaneous pedicle limberg flap for facial reconstruction.

Background: A residual dog-ear arising from the traditional Limberg flap transposition sometimes influences the cosmetic outcomes, and the Limberg flap with a subcutaneous pedicle is an innovation applicable to a variety of facial defects and free from the dog-ear.

Objective: To investigate the outcome of the subcutaneous pedicle Limberg flap for the reconstruction of medium-sized facial skin defects.

Materials And Methods: From August 2002 to June 2004, the subcutaneous pedicle Limberg flap was designed to repair facial skin defects in 17 patients (19 flaps), and the size of the lesions ranged from 2.

[Experimental study of human skin fibroblasts cultured in three-dimension(3D)].

Objective: To investigate the biological characters of human skin fibroblasts in fibroblast populated collagen lattice (FPCL).

Methods: The human fibroblasts were cultured in 3D and the collagen of the rat tail was also prepared. They were examined with the comprising cell cycle and apoptosis, mRNA expression of TGF beta1, and fibronectin, and cell morphology.

[A clinical pathological study on cavernous venous malformation of the body surface].

Objective: To investigate the clinical pathology of cavernous venous malformations of the body surface.

Methods: Tissue samples of cavernous venous malformations from 42 cases were stained with hematoxylin and eosin to observe the pathologic structure. The clinical manifestations and case history were summarized accordingly.

[The effects of chitosan on different-derived fibroblasts].

Objective: To investigate the effects of chitosan on the biological activities of the fibroblasts derived from different tissues.

Methods: The biological activities of the fibroblasts derived from different tissues were evaluated with a MTT method for fibroblast proliferation, photic and electronic microscope for morphologic and subcellular structure, 3H-proline uptake method for collagen secretion and ELISA box for the secretion of TGF-beta 1, FGF-AB, and IL-8.

Results: This study showed that the chitosan inhabited the proliferation of the fibroblasts and the secretion of the TGF-beta 1, FGF-AB and collagen of the fibroblasts with a dose-depended manner in the normal skin, hypertrophic scar and keloid groups, but it stimulated the IL-8.

[The role of releasing the fibrous bundles across levator muscle in correcting congenital blepharoptosis].

Objective: To investigate the role of releasing the fibrous bundles across the levator muscle between the medial canthus and lateral canthsus near the top of tarsus in the correction of the congenital blepharoptosis.

Methods: Twenty-seven patients with 40 eyes of blepharoptosis were undergoing the treatment. It was performed by releasing the fibrous bundles across the levator muscle between the medial canthus and lateral canthsus near the top of tarsus to correct the mild and moderate blepharoptosis.

[The expression and significance of structural proteins, VEGF and Ang-1 in cavernous venous malformations of the body surface].

Objective: To study the expression and significance of structural proteins, VEGF and Ang-1 in cavernous venous malformations of the body surface.

Methods: Tissue samples came from 25 cases of cavernous venous malformations, 12 cases of normal moderate veins and 12 cases of normal small veins. Envision immunohistochemical stain was used to investigate the expression of IV collagen, fibronectin, laminin, VEGF and Ang-1.