Publications by authors named "Tian-mei Qian"
Article Synopsis
- Neurotrophic factors like nerve growth factor promote nerve regeneration but have limitations such as a short lifespan and difficulty crossing the blood-brain barrier.
- Let-7, a human microRNA, regulates nerve growth factor and is crucial for peripheral nerve healing, with anti-let-7a identified as the most effective molecule for this purpose.
- The combination of let-7a antagomir with a hydrogel in a chitosan conduit demonstrated successful nerve regeneration in a rat model, offering a promising approach for in vivo nerve repair.
The regenerative capacity of peripheral nerves is limited after nerve injury. A number of growth factors modulate many cellular behaviors, such as proliferation and migration, and may contribute to nerve repair and regeneration. Our previous study observed the dynamic changes of genes in L4-6 dorsal root ganglion after rat sciatic nerve crush using transcriptome sequencing.
View Article and Find Full Text PDFNovel miRNA, miR-sc14, promotes Schwann cell proliferation and migration.
Neural Regen Res
September 2019
Article Synopsis
- MicroRNAs are short non-coding RNAs that play crucial roles in biological functions, including the repair and regeneration of peripheral nerves.
- In a study using a rat model, the expression of miR-sc14 was found to increase shortly after sciatic nerve injury, promoting the proliferation and migration of Schwann cells, which are essential for nerve repair.
- These findings suggest that targeting miR-sc14 could be a potential strategy for enhancing recovery from peripheral nerve injuries.
Article Synopsis
- MicroRNAs (miRNAs), specifically miR-3099, play a key role in regulating Schwann cell behavior following peripheral nerve injury.
- In a study, real-time PCR was used to measure miR-3099 expression levels in rat sciatic nerves over time after nerve crush, showing that miR-3099 levels increased post-injury.
- Further experiments revealed that higher levels of miR-3099 enhanced Schwann cell proliferation and migration, while lower levels inhibited these processes, with possible target genes identified affecting these functions.
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively adjust gene expression in multifarious biological processes. However, the regulatory effects of miRNAs on Schwann cells remain poorly understood. Previous microarray analysis results have shown that miRNA expression is altered following sciatic nerve transaction, thereby affecting proliferation and migration of Schwann cells.
View Article and Find Full Text PDF[The preparation of rabbit antiserum against gekko japonicus Hoxc10 and it's property identification].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
October 2011
Aim: Prepare the rabbit antiserum against gecko japonicus Hoxc10 and to identify its properties.
Methods: Prokaryotic expression vector of g-Hoxc10 were constructed and then transform into E.coli (BL21).