Publications by authors named "Tian-Zhu Chao"
Article Synopsis
- Radiation-induced lung injury (RILI) is a major complication of radiation therapy, and researchers have found that long non-coding RNAs (lncRNAs) play a key role in its development.
- In a study using mouse models, researchers examined lung tissues after exposure to X-ray irradiation, identifying significant changes in the expression of mRNAs, miRNAs, and lncRNAs, which were mapped in a lncRNA-miRNA-mRNA ceRNA axis.
- The findings suggest key pathways and regulatory mechanisms involved in RILI, highlighting the importance of dysregulated gene expression, particularly the role of BNIP1 in promoting cellular apoptosis after radiation exposure.
Previous studies have documented important roles for microRNA-147 (miR-147) in inflammation, radiation-induced injury, cancer, and a range of other diseases. Murine lungs exhibit high levels of miRNA, mRNA, and lncRNA expression. However, very little research to date has focused on the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) networks associated with miR-147, and the regulation of lncRNAs and miRNAs in this setting remains poorly understood.
View Article and Find Full Text PDFBackground: Radiation-induced lung injury (RILI) is a critical factor that leads to pulmonary fibrosis and other diseases. LncRNAs and miRNAs contribute to normal tissue damage caused by ionizing radiation. Troxerutin offers protection against radiation; however, its underlying mechanism remains largely undetermined.
View Article and Find Full Text PDFBackground: Prior evidence has demonstrated that miR-147 can regulate cellular proliferation, migration, apoptotic death, inflammatory responses, and the replication of viruses through its interactions with specific mRNA targets. LncRNA-miRNA-mRNA interactions are often found in various biological processes. No studies have documented lncRNA-miRNA-mRNA regulatory interactions in miR-147 mice.
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