Influence of fluid-attenuated inversion-recovery on stroke apparent diffusion coefficient measurements and its clinical application.

Background And Purpose: The application of a fluid-attenuated inversion-recovery pulse with a conventional diffusion-weighted MRI sequence (FLAIR DWI) decreases the partial volume effects from cerebrospinal fluid on apparent diffusion coefficient (ADC) measurements. For this reason, FLAIR DWI may be more useful in the evaluation of ischemic stroke, but few studies have looked at the effect of FLAIR on ADC measurements in this setting. This study quantitatively compares FLAIR DWI and conventional DWI in ischemic stroke of varying ages to assess the potential advantages of this technique.

Regional diffusion changes of cerebral grey matter during normal aging--a fluid-inversion prepared diffusion imaging study.

Background And Purpose: Although diffusion characteristics of white matter (WM) and its aging effects have been well described in the literature, diffusion characteristics of grey matter (GM), especially the cortical GM, have not been fully evaluated. In the present study, we used the fluid-inversion prepared diffusion imaging (FLIPD) technique to determine if there are age-related water diffusivity changes in GM.

Materials And Methods: 120 healthy volunteers were recruited for our study.

Lipid signal in evaluation of intracranial meningiomas.

Background: Using magnetic resonance imaging, diagnosis of malignant meningioma from benign meningioma with atypical features is uncertain. We evaluated the value of lipid signal in differentiating intracranial meningiomas.

Methods: 1H-magnetic resonance spectroscopy (MRS) using a point resolved spectroscopy (TR/TE 1000/144 ms) sequences were performed on 34 patients on a 3.

Diagnostic value of contrast-enhanced fluid-attenuated inversion-recovery MRI for intracranial tumors in comparison with post-contrast T1W spin-echo MRI.

Background: Contrast-enhanced fluid-attenuated inversion-recovery (FLAIR) magnetic resonance imaging (MRI) has been reported to have higher sensitivity for detecting leptomeningeal disease compared with contrast-enhanced T1-weighted MRI (CE T1WI). However, currently there are no studies showing the potential value of clinical applications of contrast-enhanced FLAIR (CE FLAIR) sequence in diagnosing intracranial tumors in a larger group of patients. The purpose of this study was to evaluate the diagnostic value of CE FLAIR in comparison with CE T1WI for intracranial tumors and to provide more information for clinical diagnosis and therapy.

[Diffusion tensor tracking of cerebral white matter fibers: a preliminary study].

Objective: To study the efficacy of diffusion tensor tracking (DTT) in study of the normal and abnormal cerebral white matter fiber.

Methods: Ten normal adult volunteers, 5 males and 5 females, aged 40.9 (24-65), and 28 patients with cranial tumors, 9 males and 19 females, aged 43.

[The value of diffusion MR imaging in judging pathological changes of brain multiple sclerosis].

Objective: To analyze the findings of MR diffusion weighted imaging (DWI) and diffusion tensor Imaging (DTI) in patients with multiple sclerosis (MS), and to explore their role in reflecting the pathological changes of MR lesions.

Methods: DWI and DTI were performed on 41 MS cases and 25 sub-acute brain infarct cases which used as control group. The appearances of ADC maps, EADC maps and FA maps in patients of both groups were analyzed.

[Value of magnetization transfer imaging in judging microchanges lesions in normal-appearing white matter of multiple sclerosis].

Objective: To explore the value of magnetization transfer imaging (MTI) in judging microscopic lesions in normal-appearing white matter of multiple sclerosis (MS).

Methods: Forty-one patients with brain MS, 17 males and 24 females, aged 13 approximately 65, and 21 healthy people, 8 males and 13 females, aged 18 approximately 57, used as controls underwent magnetic resonance imaging (MRI) using 3D-spoiled grass (3D-SPGR) series, to scan the whole brain with saturated pulses on and off respectively. The signal values were measured directly in the pictures of these 2 series.

[Prognostic value of MRI and 1H MRS in patients with temporal lobe epilepsy].

Objective: To evaluate the prognostic value of hippocampal MRI scan, MRI volumetry and 1H MRS in patients with temporal lobe epilepsy (TLE).

Methods: 50 intractable TLE patients operated in Huashan hospital were studied. Before surgery, traditional MRI scans were used to exclude tumor and vascular malformation of the brain.

Postmastectomy radiotherapy in premenopausal Vietnamese and Chinese women with breast cancer treated in an adjuvant hormonal therapy study.

Background: Adjuvant postmastectomy radiotherapy (RT) decreases the risk of local recurrence of breast cancer and may increase overall survival (OS).

Methods And Materials: After mastectomy, 656 premenopausal Vietnamese and Chinese women with clinical Stage II-IIIA breast cancer, in a clinical trial of adjuvant surgical oophorectomy and tamoxifen, were treated with adjuvant RT according to the availability in the institution. The short-term disease recurrence and OS experience of these 656 women were analyzed using univariate and multivariate methods.

Oophorectomy and tamoxifen adjuvant therapy in premenopausal Vietnamese and Chinese women with operable breast cancer.

Purpose: In 1992, the Early Breast Cancer Trialists' Collaborative Group reported that a meta-analysis of six randomized trials in European and North American women begun from 1948 to 1972 demonstrated disease-free and overall survival benefit from adjuvant ovarian ablation. Approximately 350,000 new cases of breast cancer are diagnosed annually in premenopausal Asian women who have lower levels of estrogen than western women.

Patients And Methods: From 1993 to 1999, we recruited 709 premenopausal women with operable breast cancer (652 from Vietnam, 47 from China) to a randomized clinical trial of adjuvant oophorectomy and tamoxifen (20 mg orally every day) for 5 years or observation and this combined hormonal treatment on recurrence.

Mastectomy and oophorectomy by menstrual cycle phase in women with operable breast cancer.

Background: It is unclear whether the phase of the menstrual cycle in which primary surgical treatment occurs influences disease-free survival (DFS) and overall survival (OS) in premenopausal women with breast cancer. We investigated this question in the context of a clinical trial comparing mastectomy alone with mastectomy plus adjuvant oophorectomy and tamoxifen in premenopausal women with operable breast cancer.

Methods: The date of the first day of the last menstrual period (LMP) was used to estimate the phase of the menstrual cycle when the surgeries were done.