Publications by authors named "Tian-Ze Lu"
Article Synopsis
- The text serves to correct previously published information in the article with DOI: 10.1371/journal.pone.0170729.
- It likely addresses specific errors or inaccuracies that were identified after the original publication.
- The correction may include updated data, methods, or conclusions to enhance the accuracy and reliability of the findings presented in the original article.
Article Synopsis
- This study investigates the potential of long non-coding RNAs (lncRNAs) in peripheral blood as non-invasive biomarkers for acute rejection (AR) in kidney transplants.
- Researchers analyzed lncRNA expression profiles in 150 blood samples from both pediatric and adult transplant recipients to identify differences between those experiencing AR and those who are not.
- They identified 23 lncRNAs common to both groups that could effectively distinguish AR cases, and created a risk score using two significant lncRNAs that showed strong diagnostic performance, making them promising candidates for AR detection in kidney transplant patients.
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults, and this study focused on analyzing microRNA (miRNA) expression profiles to distinguish between tumors with mutant and wild-type mutation statuses.
- The researchers identified 33 differentially expressed miRNAs, 11 of which were significantly associated with overall survival in patients with wild-type status, contributing to a newly developed mutation-specific miRNA signature.
- This miRNA signature, involving 11 key miRNAs, has the potential to act as a new prognostic biomarker for ccRCC patients, potentially aiding in patient management and treatment strategies.
Article Synopsis
- A meta-analysis was conducted to evaluate the effectiveness of remote ischemic conditioning (RIC) on improving kidney transplant graft function using data from randomized controlled trials (RCTs).
- Six RCTs with a total of 651 kidney transplant recipients were analyzed, showing that RIC could potentially reduce the incidence of delayed graft function (DGF), although the results were not statistically significant.
- The study concluded that while RIC might have some protective effects on kidney grafts, more comprehensive and larger RCTs are needed to confirm its clinical benefits.
Article Synopsis
- - Chromophobe renal cell carcinoma (chRCC) is a prevalent kidney cancer subtype, and the study focused on 58 untreated chRCC patients to explore their genome-wide microRNA (miRNA) expression profiles.
- - A total of 105 differentially expressed miRNAs were identified between tumor tissues and adjacent normal tissues, with an impressive 96.3% accuracy in distinguishing samples based on miRNA signatures.
- - Specific miRNAs, particularly mir-191, mir-19a, mir-210, and mir-425, were linked to patient survival outcomes, with mir-210 identified as a significant independent factor for recurrence-free survival (RFS).
Article Synopsis
- Ischemic preconditioning (IPC) helps protect the kidneys from damage caused by ischemia-reperfusion injury (IRI), although the exact mechanisms are still not fully understood.* -
- In a study with male Sprague-Dawley rats, different treatment groups were established to assess how IPC affects renal function, blood flow, and key nitric oxide synthase levels following vascular clamping.* -
- Results showed that IPC significantly improved kidney function and blood flow, linked to increased levels of endothelial and inducible nitric oxide synthase (eNOS/iNOS) and nitric oxide (NO), though these benefits were negated when nitric oxide production was inhibited.*
Papillary renal cell carcinoma (pRCC) is the second most prevalent subtype of kidney cancers. In the current study, we analyzed the global microRNA (miRNA) expression profiles in pRCC, with the aim to evaluate the relationship of miRNA expression with the progression and prognosis of pRCC.A total of 163 treatment-naïve primary pRCC patients were identified from the Cancer Genome Atlas dataset and included in this retrospective observational study.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effect of high-dose erythropoietin (EPO) on kidney graft function after transplantation, aiming to clarify its efficacy due to inconclusive findings from previous trials.
- A meta-analysis of 4 randomized controlled trials involving 356 patients showed a trend towards reduced delayed graft function in the EPO group, but it wasn't statistically significant.
- The results suggest that while high-dose EPO might help protect kidney function, it does not significantly raise the risk of adverse events compared to placebo.
A tumor-specific microRNA signature predicts survival in clear cell renal cell carcinoma.
J Cancer Res Clin Oncol
July 2015
Article Synopsis
- * Researchers analyzed miRNA expression profiles from tumor tissues and adjacent normal tissues in ccRCC patients, applying various statistical analyses to establish correlations with survival rates.
- * A total of 147 differentially expressed miRNAs were identified, leading to the creation of a tumor-specific signature of 22 miRNAs, which was validated as an independent prognostic factor for ccRCC.
Article Synopsis
- Human cancers rely on vascularization for growth, invasion, and metastasis, with endothelial progenitor cells (EPCs) playing a key role in this process.
- Recent studies show an increase in circulating EPCs (CEPCs) in cancer patients, linking their levels to clinical outcomes and making them a potential biomarker for diagnosis and prognosis.
- The review emphasizes the need for improved detection methods and more extensive clinical research to better understand the role and significance of CEPCs in cancer treatment and outcomes.
Article Synopsis
- - The study investigates the link between HLA-G 14-bp insertion/deletion polymorphism and cancer risk, finding mixed results in existing research.
- - An analysis of 14 studies involving over 2,300 cancer patients revealed no overall significant association, but suggested a notable connection for Asian populations and breast cancer cases.
- - The findings imply that HLA-G polymorphism may affect cancer risk, particularly for breast cancer among Asians, indicating a need for further comprehensive studies to confirm these results.
Background: Transforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.
Methods: Eligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database.