Size Reduction to Enhance Crystal-to-Liquid Phase Transition Induced by -to- Photoisomerization Based on Molecular Crystals of Phenylbutadiene Ester.

Harnessing the photoinduced phase transitions in organic crystals, especially the changes in shape and structure across various dimensions, offers a fascinating avenue for exact spatiotemporal control, which is crucial for developing future smart devices. In our study, we report a new photoactive molecular crystal made from ()-2-(3-phenyl-allylidene)malonate (()-PADM). When exposed to ultraviolet (UV) light at 365 nm, this compound experiences an -to- photoisomerization in liquid solution and a crystal-to-liquid phase transition in solid crystals.

Risk factors for Bakri balloon tamponade failure in the management of postpartum hemorrhage.

Objective: To predict risk factors for Bakri balloon tamponade (BBT) failure in the management of postpartum hemorrhage (PPH).

Methods: The data of 599 patients who underwent BBT were retrospectively analyzed from January 1, 2017 to December 31, 2021 in a tertiary hospital in Shanghai, East China. The patients were divided into the failure group and the success group.

Engineering Photomechanical Molecular Crystals to Achieve Extraordinary Expansion Based on Solid-State [2 + 2] Photocycloaddition.

Photomechanical molecular crystals are promising candidates for photoactuators and can potentially be implemented as smart materials in various fields. Here, we synthesized a new molecular crystal, ()-3-(naphthalen-1-yl)acrylaldehyde malononitrile (()-), that can undergo a solid-state [2 + 2] photocycloaddition reaction under visible light (≥400 nm) illumination. ()- microcrystals containing symmetric twinned sealed cavities were prepared using a surfactant-mediated crystal seeded growth method.

Acoustic features as novel predictors of difficult laryngoscopy in orthognathic surgery: an observational study.

Background: The evaluation of the difficult intubation is an important process before anaesthesia. The unanticipated difficult intubation is associated with morbidity and mortality. This study aimed to determine whether acoustic features are valuable as an alternative method to predict difficult laryngoscopy (DL) in patients scheduled to undergo orthognathic surgery.

Motorized Macrocycle: A Photo-responsive Host with Switchable and Stereoselective Guest Recognition.

Designing photo-responsive host-guest systems can provide versatile supramolecular tools for constructing smart systems and materials. We designed photo-responsive macrocyclic hosts, modulated by light-driven molecular rotary motors enabling switchable chiral guest recognition. The intramolecular cyclization of the two arms of a first-generation molecular motor with flexible oligoethylene glycol chains of different lengths resulted in crown-ether-like macrocycles with intrinsic motor function.

Color-tunable single-fluorophore supramolecular system with assembly-encoded emission.

Regulating the fluorescent properties of organic small molecules in a controlled and dynamic manner has been a fundamental research goal. Although several strategies have been exploited, realizing multi-color molecular emission from a single fluorophore remains challenging. Herein, we demonstrate an emissive system by combining pyrene fluorophore and acylhydrazone units, which can generate multi-color switchable fluorescent emissions at different assembled states.

Towards a hexa-branched [7]rotaxane from a [3]rotaxane via a [2+2+2] alkyne cyclotrimerization process.

A facile synthesis methodology to obtain a crown ether-based hexa-branched [7]rotaxane, has been achieved by using Co-catalyzed [2+2+2] alkyne cyclotrimerization from a [3]rotaxane. The [2+2+2] alkyne cyclotrimerization process, which requires only 10 mol% of Co2(CO)8 as a catalyst and affords an efficient production of target rotaxanes, represents a new strategy for the construction of highly complicated dendritic rotaxanes.

[Molecular mechanisms of recursive splicing events in long introns of eukaryotes].

Recursive splicing refers to the biological process that long introns are removed in multiple steps during pre-mRNA splicing. In comparison to large introns (>10 kb), most introns in higher eukaryotic genomes are removed in one step during transcription. Previous studies have revealed that recursive splicing events play important roles in many biological processes, including the pathogenesis and development of diseases.

Bistable [2]rotaxane encoding an orthogonally tunable fluorescent molecular system including white-light emission.

Orthogonally tunable multicolor fluorescence including white-light emission was achieved using a dual-component molecular system. Under external acid/base stimuli, we were able to change the fluorescence of a mixture of two fluorescent molecular switches in an orthogonal and reversible manner, hence generate emission of multiple colors from blue to yellow, including white light (CIE (0.29, 0.

Dynamic Self-Assembly of Gold/Polymer Nanocomposites: pH-Encoded Switching between 1D Nanowires and 3D Nanosponges.

The design of tunable dynamic self-assembly of nanoparticles with switchable assembled dimensions and morphologies is a challenging goal whose realization is vital for the evolution of smart nanomaterials. Herein, we report on chitosan polymer as an effective supramolecular "glue" for aldehyde-modified Au nanoparticles to reversibly modulate the states of self-assembled nanocomposites. By simultaneous integration of dynamic covalent Schiff base interactions and noncovalent hydrogen bonds, the chitosan/Au nanocomposites could reversibly transform their assembled morphologies from one-dimensional nanowires to three-dimensional nanosponges in response to the variation of pH value.

A novel 22-bp deletion mutation in a Chinese family with X-linked hypohidrotic ectodermal dysplasia.

X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of the ectodermal dysplasias characterized by an abnormal development of eccrine sweat glands, hair and teeth. Pathogenic mutations in the ED1 gene have been identified. In this family, a 22-bp deletion mutation of exon 8 in the ED1 gene was found in the affected members but not in the healthy individuals and 100 unrelated controls.