Publications by authors named "Tian-Yi Lyu"
[Study on discovery of efficacy markers for Dachaihu Decoction and its action mechanism].
Zhongguo Zhong Yao Za Zhi
April 2022
Article Synopsis
- Dachaihu Decoction is a traditional Chinese herbal formula known for balancing lesser yang and reducing internal heat, but its specific quality indicators and mechanisms of action are not fully understood.
- This study used literature review, molecular biology techniques, and network pharmacology to identify key efficacy markers and explore their mechanisms, focusing on the five principles for assessing quality in Chinese herbal medicine.
- The research revealed potential efficacy markers, including Saikosaponin B_2 and baicalin, which showed effective anti-inflammatory properties and suggested that these markers engage with MAPK and NF-κB pathways to regulate inflammation.
Astragali Radix is the elixir for invigorating Qi, with the effects of invigorating Qi, promoting Yang and nourishing the body. With the deepening researches on the chemical constituents of Astragali Radix, it is used more extensively in clinical application. Based on systematic traditional Chinese medicine theory, in this paper, we characterized the effect of Astragali Radix on invigo-rating Qi from the molecular level, and explored the markers of Astragali Radix on invigorating Qi.
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