Exact dispersion relation of the quantum Langmuir wave.

The normal modes, i.e., the eigensolutions to the dispersion relation equation, are the most fundamental properties of a plasma.

Kinetic investigations of nonlinear electrostatic excitations in quantum plasmas.

For plasmas in an extremely high-density state, like stellar cores or compressed fuel in inertial fusion facilities, their behavior turns out to be quite different when compared with those plasmas in interstellar space or magnetic confinement devices. To figure out those differences and uncover the kinetic physics in electrostatic excitations, a quantum kinetic code solving Wigner-Poisson equations has been developed. Basic plasmon decay, Landau damping, and two-stream instability of extremely high-density plasmas are investigated by using our newly developed code.

Kinetic studies of exchange-correlation effect on the collective excitations of warm dense plasmas.

The exchange-correlation of electrons, as a fundamental effect in quantum mechanics, plays an important role in the collective motions of electrons in warm dense matter. We derive the quantum kinetic equations based on the time-dependent Kohn-Sham equation. By using a temperature-dependent functional for the exchange correlation, the excitations of electrostatic waves are analyzed under the adiabatic local density approximation (ALDA).

Kinetic study of quantum two-stream instability by Wigner approach.

Classical plasma are typically of low density and/or high temperature. Two of its basic properties are Landau damping and two-stream instabilities. When increasing the plasma density, quantum effects appear and beam-plasma interactions show behavior different from the classical cases.

Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents.

As our research focuses on anticancer drugs, a series of novel derivatives of flexicaulin A (FA), an ent-kaurene diterpene, condensed with an aromatic ring were synthesized, and their antiproliferative activities against four human cancer cell lines (TE-1, EC109, MCF-7, and MGC-803) were evaluated. The activities of most of the new compounds were better than those of FA. Compound 2y exhibited the best activity with an IC50 value reaching 0.

The design, synthesis and anti-tumor mechanism study of new androgen receptor degrader.

Targeted protein degradation using small molecules is a novel strategy for drug development. In order to solve the problem of drug resistance in the treatment of prostate cancer, proteolysis-targeting chimeras (PROTAC) was introduced into the design of anti-prostate cancer derivatives. In this work, we synthesized two series of selective androgen receptor degraders (SARDs) containing the hydrophobic degrons with different linker, and then investigated the structure-activity relationships of these hybrid compounds.

Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate.

As our research focus on anticancer drugs, two series of novel derivatives of Flexicaulin A (FA), an ent-kaurene diterpene, condensation with amino acid trifluoroacetate were synthesized, and their anti-proliferative activity against four human cancer cell lines (TE-1, MCF-7, A549 and MGC-803) were evaluated. Compared with FA, the anticancer activity and solubility of most derivatives were significantly improved. Among them, compound 6d had the best activity, and its IC value against Esophageal cancer cells (TE-1) was up to 0.

Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents.

As a continuation of our research on developing potent and potentially safe anti-proliferative agents, two series of novel Jiyuan Oridonin A-1,2,3-triazole-azole hybrids were designed, synthesized and evaluated for their anti-proliferative activity against four selected cancer cell lines (MGC-803, MCF-7, PC-3, Eca-109). Some compounds with better growth inhibitory effects were chosen to carry out further studies in A549 and SMMC-7721. Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected.