Publications by authors named "Tian-Wei Li"
A Comparison of the Decline in Glomerular Filtration Rate between Elderly Patients with Diabetes and those without Diabetes in Southwest China.
Endocr Metab Immune Disord Drug Targets
September 2024
Article Synopsis
- The study aimed to examine how high blood sugar levels affect kidney function decline (measured by eGFR) in older adults.
- A comparison of diabetic and non-diabetic individuals revealed that diabetes significantly worsens kidney function decline over four years, with diabetic patients experiencing a 9.29% drop in eGFR versus 5.32% in non-diabetics.
- The findings highlight a growing prevalence of diabetes among the elderly, rising from 12.67% to 16.68% between 2017 and 2021, and the importance of monitoring kidney health in this group.
Vascular dementia (VD) has been one of the most serious public health problems worldwide. It is well known that cerebral hypoperfusion is the key pathophysiological basis of VD, but it remains unclear how global genes in hippocampus respond to cerebral ischemia-reperfusion. In this study, we aimed to reveal the global gene expression profile in the hippocampus of VD using a rat model.
View Article and Find Full Text PDFApoptosis and the dysfunction of the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP-responsive element binding protein (CREB) signaling pathway have a key role in memory impairment in vascular dementia (VaD), a challenging clinical problem. Yifei Xuanfei Jiangzhuo formula (YXJF), a Chinese herbal decoction, has been used to treat VaD in clinical practice and has produced positive outcomes; however, convincing evidence is currently lacking. The present study aimed to investigate the effects of YXJF on memory impairment in rats with cerebral ischemia/reperfusion and to explore the underlying mechanism.
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