promotes granulosa cells apoptosis by targeting in broody goose ().

Goose () are highly broody with low egg production, and large number of granulosa cells undergo apoptosis during broodiness. Our previous study has found that was highly abundant in the ovary of goose with broodiness phenotype. However, the mechanism that regulates granulosa cells function remains unclear.

Lung adenocarcinoma harboring rare epidermal growth factor receptor L858R and V834L mutations treated with icotinib: A case report.

Background: Epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors are widely used for the treatment of non-small-cell lung cancer with mutations. However, patients with rare, even compound mutations have different responses to EGFR-tyrosine-kinase inhibitors, which bring uncertainty to clinical treatment.

Case Summary: A 45-year-old female patient presented with a 3-mo history of cough and white sputum without chest pain.

Investigative therapy for advanced esophageal cancer using the option for combined immunotherapy and chemotherapy.

Advanced esophageal cancer has limited therapeutic options and a poor outcome. The efficacy of immunotherapy, as the first-line treatment of advanced esophageal cancer, is uncertain. A stage IV advanced esophageal cancer patient received the first-line treatment with a combination of pembrolizumab and chemotherapy.

Comparative transcriptome analysis reveals PERP upregulated during Salmonella Enteritidis challenge in laying ducks.

Salmonella Enteritidis (SE) can be transmitted to eggs through cecum or the ovary from infected layers and causes food poisoning in humans. The mechanism of cecal transmission has been extensively studied. However, the mechanism and route of transovarian transmission of SE remain unclear.

A novel photoelectrochemical sensor based on photocathode of PbS quantum dots utilizing catalase mimetics of bio-bar-coded platinum nanoparticles/G-quadruplex/hemin for signal amplification.

Photocathode based on p-type PbS quantum dots (QDs) combing a novel signal amplification strategy utilizing catalase (CAT) mimetics was designed and utilized for sensitive photoelectrochemical (PEC) detection of DNA. The bio-bar-coded Pt nanoparticles (NPs)/G-quadruplex/hemin exhibited high CAT-like activity following the Michaelis-Menten model for decomposing H2O2 to water and oxygen, whose activity even slightly exceeded that of natural CAT. The bio-bar-code as a catalytic label was conjugated onto the surface of PbS QDs modified electrodes through the formed sandwich-type structure due to DNA hybridization.

Selection and application of agricultural wastes as solid carbon sources and biofilm carriers in MBR.

This paper examined the feasibility of agricultural wastes used as solid carbon sources and the effect of determined agricultural wastes on improving denitrification. Eight agricultural wastes were evaluated in MBR tests to find out their carbon release capacity, denitrification potential, leaching elements and surface properties. The results showed that retinervus luffae fructus, wheat straw, corncob and rice straw had higher carbon release capacity with COD of 13.

[The expression analysis of Grb10 during mouse embryonic development].

Grb10 gene expression was analyzed in fetus and four organs during gestation process using the real-time RT-PCR and in situ hybridization. The real-time RT-PCR analysis result showed that the expression of Grb10 in whole embryos is throughout E8.5 to E19.