[Lactic acid inhibits the formation of semen-derived amyloid fibrils].

Objective: To investigate the inhibitory effect of lactic acid on semen-derived amyloid (SEVI) fibril formation.

Methods: PAP248-286 (2 mg/mL) was incubated with 4.0, 2.

Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition.

The persistence of HIV in resting memory CD4 T cells at a latent state is considered as the major barrier on the path to achieve a cure for HIV. Proteasome inhibitors (PIs) were previously reported as latency reversing agents (LRAs) but the mechanism underlying this function is yet unclear. Here we demonstrate that PIs reactivate latent HIV ex vivo without global T cell activation, and may facilitate host innate immune responses.