Exploring the determinants to accept dementia screening among patients at high risk of dementia based on the theory of planned behavior: A cross-sectional study.

Background: Dementia represents a major public health challenge. Despite numerous initiatives promoting screening for early cognitive impairment to help prevent or delay its onset, participation remains limited. Moreover, there is limited evidence regarding screening intentions and predictors among populations at high risk of dementia.

Capture primed pluripotency in guinea pig.

Guinea pigs are valuable models for human disease research, yet the lack of established pluripotent stem cell lines has limited their utility. In this study, we isolate and characterize guinea pig epiblast stem cells (gpEpiSCs) from post-implantation embryos. These cells differentiate into the three germ layers, maintain normal karyotypes, and rely on FGF2 and ACTIVIN A signaling for self-renewal and pluripotency.

Toward one-step As(III) removal in ultrafiltration with in situ BioMnO cake layer: Mechanism and feasibility insights.

Inorganic arsenic (As) is one of the most significant chemical contaminants in drinking water worldwide. Although membrane-based technologies are commonly used for As removal, they often encounter challenges including complex operation, high energy consumption, and the need for chemical addition. To address these challenges, we proposed a one-step ultrafiltration (UF) process empowered by in situ biogenic manganese oxides (BioMnO) cake layers without any additional chemicals, to treat source water contaminated with both As and manganese (Mn).

A first-in-human phase 1/2 dose-escalation study of MAK683 (EED inhibitor) in patients with advanced malignancies.

Purpose: MAK683, a first-in-class and highly selective allosteric inhibitor of the embryonic ectoderm development subunit of polycomb repressive complex 2, has shown sustained antitumor activity in tumor xenograft models. This first-in-human phase 1/2 study evaluated the safety, pharmacokinetics (PK), and clinical activity of single-agent MAK683 in advanced malignancies.

Methods: MAK683 was administered fasted once daily or twice daily continuously in 28-day treatment cycles.

Distribution of microbial taxa and genes degrading halogenated organic pollutants in the mangroves.

Anthropogenic activities have led to serious contamination of halogenated organic pollutants (HOPs), such as PCBs, PBDEs, and HBCDs, in the mangrove wetland. Biodegradation of HOPs is generally driven by environmental microorganisms harboring dehalogenase genes. However, little is known if HOPs can affect the distributions of HOPs-degrading bacteria and dehalogenase genes in the mangrove wetlands.

MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production.

Uranium poisoning, particularly from exposure to Depleted Uranium (DU), occurs when uranyl ions enter the bloodstream and bind primarily to transferrin, osteopontin, and albumin before entering cells via corresponding receptors on renal tubular membranes, leading to cellular damage. Uranium poisoning remains a significant clinical challenge, with no ideal treatment currently available. In this study, we investigate the therapeutic potential of human umbilical cord-derived mesenchymal stem cell exosomes (MSC-EXs) in mice exposed to DU.

Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents.

Background: Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. However, the evidence is limited.

Evaluation of muscle mass relative to weight/sitting height improves the association with physical performance.

Objectives: To compare relationships of appendicular skeletal muscle mass (ASM) with the function of the upper and lower extremities, after the former has been adjusted by five body size variables: height; weight; body mass index (BMI); sitting height; and weight/sitting height.

Study Design: A cross-sectional study of data derived from the baseline phase of the Physical Activity and Health in Older Women Study.

Main Outcome Measures: ASM was measured by bioelectrical impedance analysis.

Beneficial effects of ε-polylysine on growth performance, antioxidant capacity, intestinal morphology, and gut microbiota in broilers fed a lysine-deficient diet.

This study was conducted to investigate the effects of dietary ε-polylysine supplementation on growth performance, antioxidant capacity, intestinal morphology, and gut microbiota in broilers fed a lysine-deficient diet. A total of 960 one-day-old yellow-feathered broilers were randomly allocated into six groups with eight replicates and 20 birds per replicate. Birds in the six groups were fed a lysine-deficient basal diet (-0.

Ictal EEG of benign convulsion with mild gastroenteritis with in infants and children.

Objective: There are fewer reports on the ictal electroencephalogram(EEG) of convulsions in infants and children with mild gastroenteritis (BCWG). Our study retrospectively analyzed the ictal EEG characteristics of convulsive episodes of BCWG.

Methods: The seizure-phase EEGs of children diagnosed with BCWG from September 2016 to January 2022 were searched and analyzed, and a total of thirteen seizure-phase EEGs of eight cases were analyzed retrospectively.

Growing contribution to radiative forcing from China's on-farm nitrous oxide emissions requires more attention.

Agricultural systems are important emission sources of non-CO greenhouse gases (GHGs), including the relatively short-lived GHG methane (CH). As a pivotal emitter, China's CH emissions have received wide attention. For the first time, this study applied an indicator of radiative forcing-based climate footprint (RFCF) to compare the climate impacts of China's on-farm non-CO GHG emissions including CH and nitrous oxide (NO).

Metastable state preceding shear zone instability: Implications for earthquake-accelerated landslides and dynamic triggering.

Understanding the dynamic response of granular shear zones under cyclic loading is fundamental to elucidating the mechanisms triggering earthquake-induced landslides, with implications for broader fields such as seismology and granular physics. Existing prediction methods struggle to accurately predict many experimental and in situ landslide observations due to inadequate consideration of the underlying physical mechanisms. The mechanisms that influence landslide dynamic triggering, a transition from static (or extremely slow creeping) to rapid runout, remain elusive.

Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes.

Objective: Pleural metastasis (PM) is rare in patients with differentiated thyroid cancer (DTC). Radioiodine (131I) therapy has been the main treatment for postoperative metastasis and recurrence of DTC. However, clinical data on PM from DTC are limited.

A reliable unmanned aerial vehicle multi-ship tracking method.

As the global economy expands, waterway transportation has become increasingly crucial to the logistics sector. This growth presents both significant challenges and opportunities for enhancing the accuracy of ship detection and tracking through the application of artificial intelligence. This article introduces a multi-object tracking system designed for unmanned aerial vehicles (UAVs), utilizing the YOLOv7 and Deep SORT algorithms for detection and tracking, respectively.

Research on the construction of an urban underground parking space color system from the perspective of psychological perception.

Color, an intuitive element affecting human senses, can adapt to the environment of a space, evoke emotional responses, trigger and accumulate visual experiences, and enhance the effectiveness of color in shaping spatial atmosphere and reinforcing spatial divisions. In the context of rapid urban underground space development, examining the rational application of color in underground parking spaces is crucial for improving guidance, comfort, and aesthetics. This exploration is essential for achieving high-quality development in urban underground parking environments.

Clonorchiasis, Marked Eosinophilia, and the Lack of Blasts in the Circulation Delaying the Diagnosis of Pediatric B-Lymphocytic Leukemia.

Eosinophilia is rare in pediatric acute lymphoblastic leukemia. In this report, we present a case of acute lymphoblastic leukemia with marked eosinophilia, whose diagnosis was delayed because of clonorchiasis.

Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.

Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-assembling nanomedicines, employing physiochemical parameters to predict formation via machine learning.

Chorionic-based intrahepatic cholestasis in pregnancy on perinatal outcome in twin pregnancies.

This study investigates the impact of twin intrahepatic cholestasis in pregnancy (ICP) in different chorionicity scenarios on pregnancy outcome and risk factors. This retrospective study was designed to investigate the association between ICP and pregnancy outcomes and associated risk factors. Logistic regression analysis was used to verify the correlation between ICP and pregnancy outcome and the associated risk factors with the risk of ICP.

Age-related changes in bioelectrical impedance analysis-derived phase angle (PhA) and the association between PhA and sarcopenic obesity in Chinese adults.

There are limited studies on the phase angle (PhA) and sarcopenic obesity (SO) in the Chinese population. This study aimed to establish 50 kHz-PhA reference data for SO population, and to evaluate the correlation between 50 kHz-PhA and SO. A total of 10,312 participants including 5415 men and 4897 women were enrolled in this study, and their resistance and reactance at 50 kHz, and body composition parameters were measured a segmental multifrequency bioelectrical impedance analysis device (InBody 720).

Efficacy of modified posterior shoulder stretching exercises on shoulder function in subacromial impingement syndrome: A comprehensive meta-analysis.

Background: Subacromial impingement syndrome (SIS) is a common cause of shoulder pain and dysfunction. Modified posterior shoulder stretching exercises have been proposed as a treatment method aimed at improving shoulder function and reducing pain in patients with SIS. However, the efficacy of these exercises remains controversial, necessitating a systematic meta-analysis to comprehensively evaluate their effectiveness.

Maternal X chromosome pericentric inversion resulting in the genetic analysis of offspring pedigrees with deletions at Xp22.33 and Xp22.33p11.3, and duplications at Xq27.3q28: Case report.

Rationale: This study investigates the genetic cause of primary infertility and short stature in a woman, focusing on maternal X chromosome pericentric inversion and its impact on offspring genetic outcomes, including deletions at Xp22.33 and Xp22.33p11.

High-performance ternary logic circuits and neural networks based on carbon nanotube source-gating transistors.

Multi-valued logics (MVLs) offer higher information density, reduced circuit and interconnect complexity, lower power dissipation, and faster speed over conventional binary logic system. Recent advancement in MVL research, particularly with emerging low-dimensional materials, suggests that breakthroughs may be imminent if multistates transistors can be fabricated controllably for large-scale integration. Here, a concept of source-gating transistors (SGTs) is developed and realized using carbon nanotubes (CNTs).