Publications by authors named "Tian-Hui Hu"
BMC Public Health
December 2023
Article Synopsis
- Inflammatory bowel disease (IBD) poses a significant global health challenge, with its prevalence and outcomes differing widely across various countries and regions, making it essential to understand these differences for better prevention and treatment.*
-
- An analysis of 198 countries from 1990 to 2019 reveals that in 2019 there were approximately 405,000 new IBD cases and 41,000 deaths globally, with a slow decline in incidence and mortality rates especially evident in high-income regions.*
-
- Future predictions using advanced modeling indicate that the global burden of IBD will likely decrease from 2020 to 2050, although the ongoing impact of IBD, shown through increasing cases and disability-adjusted life years
Article Synopsis
- The JTB gene is upregulated in liver cancer but usually shows reduced expression in other cancers; this study investigates its role in hepatocellular carcinoma (HCC) and its interaction with the Hepatitis B surface antigen (HBsAg).
- Experimental methods included creating a HepG2 cell line that expresses HBsAg and silencing JTB using RNA interference to study their effects on cell behavior.
- The results revealed that silencing JTB increased cancer cell motility and survival, particularly in HBsAg-positive cells, suggesting JTB acts as a tumor suppressor in HBV-related HCC, and targeting it might be a viable treatment strategy.
