Cu(II)-Catalyzed Ortho-C-H Nitration of Aryl Ureas By C-H Functionalization.

A novel protocol for the aromatic ortho C-H nitration of aryl ureas with Fe(NO)·9HO is developed. The reaction utilizes CuCl·2HO as catalyst and p-TSA as additive, showing good functional group tolerance and furnishing the desired products in moderate to excellent yields.

[Experimental study on xue-bao capsules against injury of radiation or cyclophosphamide in mice].

Objective: To explore the effects of xue-bao capsules on injury of radio-or chemo-therapy in mice, in order to provide rationale behind clinical trials.

Method: xue-xu (deficiency of blood) model in mice was induced by radiation or cyclophosphamide. Leucocyte (WBC), erythrocyte (RBC), hemoglobin (Hb) and platelet (Pt) in peripheral blood as well as CFU-E and CFU-Gm in bone marrow were counted.

[Yixintong tablet's protection against experimental myocardial ischemia].

Objective: Various models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia.

Method: Models of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline) to check the indices of ECG, hemodynamics, and morphology.

Result: A dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty-minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion.

[Experimental studies on antianimia effect of shengxuesu].

Objective: Using animal anemia models to observe the antianemia effect of Shengxuesu, and to afford an experimental basis for preventing and treating anemia.

Method: Rat model of iron deficiency induced by denutrition and mouse model of nemorrhagic anemia by blood lefting were established. Indices of hemoglobin(HB), red blood cell count(RBC), hematocrit(HCT), mean corpuscular hemoglobin count(MCHC), serum iron(SI), serum ferritin (SF) and total iron-binding capacity(TIBC) were monitored.