Publications by authors named "Tian-Hao Chu"
Purpose: GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
Methods: Immunohistochemical staining was used to detect the protein levels of GPX8 in HCC tissue microarrays.
Background: Cetuximab, an inhibitor targeting EGFR, is widely applied in clinical management of colorectal cancer (CRC). Nevertheless, drug resistance induced by KRAS-mutations limits cetuximab's anti-cancer effectiveness. Furthermore, the persistent activation of EGFR-independent AKT is another significant factor in cetuximab resistance.
View Article and Find Full Text PDFBackground And Aims: The recurrence and metastasis of hepatocellular carcinoma (HCC) are mainly caused by microvascular invasion (MVI). Our study aimed to uncover the cellular atlas of MVI HCC and investigate the underlying immune infiltration patterns with radiomics features.
Methods: Three MVI positive HCC and three MVI negative HCC samples were collected for single-cell RNA-seq analysis.
Article Synopsis
- This study focuses on creating a deep pathomics score (DPS) to predict tumor recurrence in hepatocellular carcinoma (HCC) patients after liver transplantation (LT).
- Using advanced deep learning techniques, the researchers analyzed two patient datasets and identified key histological structures, particularly emphasizing the role of immune cells in recurrence risk.
- The findings show that the DPS is a reliable tool for predicting post-LT recurrence, with high classification accuracy and significant associations between specific tumor characteristics and recurrence outcomes.