Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation the CaMKII-CREB-BDNF pathway in schizophrenia.

Background: Schizophrenia (SZ), a chronic and widespread brain disorder, presents with complex etiology and pathogenesis that remain inadequately understood. Despite the absence of a universally recognized endophenotype, peripheral blood mononuclear cells (PBMCs) serve as a robust model for investigating intracellular alterations linked to SZ.

Aim: To preliminarily investigate potential pathogenic mechanisms and identify novel biomarkers for SZ.