Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation.

Background: Slow transit constipation (STC) is a disorder with delayed colonic transit. Cinnamic acid (CA) is an organic acid in natural plants, such as (Xuan Shen), with low toxicity and biological activities to modulate the intestinal microbiome.

Aim: To explore the potential effects of CA on the intestinal microbiome and the primary endogenous metabolites-short-chain fatty acids (SCFAs) and evaluate the therapeutic effects of CA in STC.