Publications by authors named "Tian Zhuang"

Background: To accurately assess disease risk, specific reference intervals for transthyretin (TTR) tetramers, misfolded proteins, and protein misfolding rates are essential. This study aimed to establish reference intervals using a robust and traceable ultrahigh performance liquid chromatography (UPLC) method and to evaluate the distribution of these biomarkers in patients with transthyretin amyloidosis (ATTR).

Methods: Serum samples from 331 healthy Chinese individuals were included.

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Background: Aging is a natural process that affects the majority of organs within the organism. The liver, however, plays a pivotal role in maintaining the organism's homeostasis due to its robust regenerative and metabolic capabilities. Nevertheless, the liver also undergoes the effects of aging, which can result in a range of metabolic disorders.

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Background: The goal of hematological response has been well established in the treatment of systemic light chain amyloidosis. However, the pattern of cardiac response remains unknown.

Objectives: This study was designed to investigate the cardiac response dynamics in patients with an early and high-quality hematological response.

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Mavacamten is a cardiac myosin inhibitor for adults with obstructive hypertrophic cardiomyopathy (HCM). Dose optimization is performed 4 weeks after starting mavacamten, guided by periodic echo measurements of Valsalva left ventricular outflow tract gradient (VLVOTg) and left ventricular ejection fraction (LVEF). Previously, a population pharmacokinetic (PPK) model was developed and exposure-response (E-R) of VLVOTg (efficacy) and LVEF (safety) was used to identify the mavacamten titration regimen with the optimal benefit/risk ratio, now included in the US prescribing information.

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Background: There is no unified prognostic scoring system for light chain cardiac amyloidosis (AL-CA), particularly stage IIIb AL-CA. This study aimed to use invasive haemodynamic information to investigate markers that can more accurately evaluate the prognosis of patients with stage IIIb AL-CA.

Methods: In this retrospective cohort study, we conducted invasive haemodynamic measurements concurrently with myocardial biopsies to diagnose AL-CA.

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Background: Cardiac involvement in amyloid light chain (AL) amyloidosis significantly influences prognosis, necessitating timely diagnosis and meticulous risk stratification.

Objectives: This prospective study aimed to delineate the molecular phenotypes of AL-cardiac amyloidosis (CA) by characterizing fibro-amyloid deposition using F-florbetapir and gallium-68-labeled fibroblast activation protein inhibitor (Ga-FAPI)-04 positron emission tomography (PET)/computed tomography (CT) imaging. The authors also proposed a novel molecular stratification methodology for prognosis.

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Objection: The rapid advancement of artificial intelligence has brought significant breakthroughs to various medical disciplines,This study aimed to compare perioperative factors and postoperative hip function recovery in primary total hip arthroplasty (THA)by evaluating the use of an artificial intelligence (AI) preoperative planning system versus traditional two-dimensional X-ray planning.

Patients And Methods: A total of 45 eligible patients underwent primary THA at Beijing Shijitan Hospital, Capital Medical University, between July 2022 and August 2022. The patients were randomly assigned to either the experimental group (n = 19) or the control group (n = 26).

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Article Synopsis
  • - The study investigates the voltage-to-mass ratio as a diagnostic tool for cardiac amyloidosis (CA) by comparing it across different patient groups and healthy controls.
  • - Researchers analyzed data from 213 CA patients and other heart-related groups, finding that CA patients had lower voltage-to-mass ratios, which were significantly associated with their condition.
  • - The optimal cut-off value for diagnosing CA, using the cross-sectional area method, was established at 16.42 mV/mm/m, showing high sensitivity and specificity and highlighting the potential for this method to replace more invasive diagnostics.
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  • Cardiac ischemia/reperfusion (I/R) injury is a significant concern for heart disease, but there's currently no effective treatment to minimize this type of heart damage.
  • This study recruited patients with acute myocardial infarction to examine the impact of plasma RIPK3 levels before and after treatment, using both patient data and lab experiments on cells and mouse models.
  • Elevated RIPK3 levels post-treatment were linked to worse outcomes, and experiments showed that RIPK3 worsens heart injury by triggering inflammation, suggesting its role as a damaging molecule that could be targeted for therapy.
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Aims: Heterologous expression of sulfur: quinone oxidoreductase (Sqr) from Halomonas mongoliensis JS01, which is responsible for oxidizing sulfide to elemental sulfur, in Thioalkalivibrio versutus (T. versutus) D301 improves desulfurization.

Methods And Results: We expressed sqr in T.

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Purpose: It has been reported that exhaustive exercise (EE) causes myocyte injury, and eventually damages the function of the myocardia. Albiflorin (AF) has anti-inflammatory, antioxidant, and anti-apoptosis effects. In this study, we determined whether AF could mitigate the EE-induced myocardial injury and research the potential mechanisms.

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The probability of cardiovascular events has been reported lower in rheumatoid arthritis (RA) patients treated with leflunomide. However, the anti-atherosclerotic and cardiovascular protective effects and metabolism of leflunomide are not explored. In this study, we assessed the potential benefits of leflunomide on atherosclerosis and revealed the underlying mechanism.

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  • The study investigates the long-term outcomes of dilated cardiomyopathy (DCM) in Chinese patients, focusing on the impact of the left ventricular (LV) hypertrabeculation phenotype.
  • Researchers examined DCM patients hospitalized between September 2002 and September 2022, comparing those with isolated DCM to those with the LV hypertrabeculation phenotype.
  • Findings reveal that while the LV hypertrabeculation phenotype is associated with a higher risk of major adverse cardiac events (MACEs) in the first five years, this effect diminishes over time, with notable differences in risk based on sex.
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Background: Amyloid light-chain (AL) amyloidosis is a multisystem disorder, with cardiac amyloid infiltration being a prevalent manifestation. This study aimed to explore the prognostic value of galectin-3 (Gal-3), a soluble marker associated with fibrosis, inflammation, heart failure, and kidney injury, in patients with cardiac AL amyloidosis.

Methods: A total of 60 patients who were diagnosed with cardiac AL amyloidosis from January 2015 to May 2018 were enrolled.

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Defect inspection of existing buildings is receiving increasing attention for digitalization transfer in the construction industry. The development of drone technology and artificial intelligence has provided powerful tools for defect inspection of buildings. However, integrating defect inspection information detected from UAV images into semantically rich building information modeling (BIM) is still challenging work due to the low defect detection accuracy and the coordinate difference between UAV images and BIM models.

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Article Synopsis
  • * Various experimental methods, including gene knockout and transcriptome analysis, showed that the absence of Oct1p disrupts mitochondrial functions, leading to issues with hyphal growth, cell adhesion, and biofilm formation in fungi.
  • * The study found that Oct1p loss decreases the virulence of Candida infections in larvae and mice, highlighting its potential as a therapeutic target for treating Candida diseases and understanding virulence in other fungi.
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Objective Variations are present in common clinical practices regarding best practice in managing hyperkalaemia (HK), there is therefore a need to establish a multi-specialty approach to optimal renin-angiotension-aldosterone system inhibitors (RAASi) usage and HK management in patients with chronic kidney disease (CKD) & heart failure (HF).This study aimed to establish a multi-speciality approach to the optimal use of RAASi and the management of HK in patients with CKD and HF. Methods A steering expert group of cardiology and nephrology experts across China were convened to discuss challenges to HK management through a nominal group technique.

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Background And Aims: The 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) guideline has recently revised the hemodynamic definition of pulmonary arterial hypertension. However, there is currently limited research on the prognosis and treatment of system lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH) patients that have been reclassified by the new hemodynamic definition. This study aims to analyze the prognosis of newly reclassified SLE-PAH patients and provide recommendations for the management strategy.

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Exhaustive exercise (EE) induces kidney injury, but its concrete mechanism has not been fully elucidated. Hepatoprotective effects of dipsacoside B (DB) have been found previously, involving in autophagy induction. However, whether DB exerts renal protective effect and its potential mechanism are still unknown.

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In this study, a novel and accurate quantitative analysis method for the direct determination of chitosan (CS) in aqueous solutions using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) is presented. By detecting the mass spectrum response intensity of a series of CS characteristic ion pairs, the sample concentration (abscissa) was linearly fitted with the total ion current (TIC) response intensity of its characteristic ion pairs (ordinate). A reliable standard curve was derived for quantifying CS in the range of 125-4000 ng/mL.

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Background: Janus kinase 2 (JAK2) mutation plays an important role in T cell immunity. However, the effect of JAK2 mutation on immunotherapy is largely uncharacterized.

Methods: In this study, we analyzed the effect of JAK2 mutation on the efficacy and outcomes of immune checkpoint inhibitor (ICI) therapy in the discovery cohort (n = 662) and the verification cohort (n = 1423).

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Article Synopsis
  • - Human cartilage is divided into three types: hyaline, elastic, and fibrocartilage, each with distinct properties that complicate tissue regeneration.
  • - Bionics, which studies and imitates nature, can enhance our understanding of cartilage anatomy and aid in tissue repair strategies.
  • - 3D bioprinting offers a cutting-edge method for creating precise cartilage models, integrating suitable materials, cells, and bionic principles to improve tissue repair outcomes.
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